肾功能对于食管癌患者^(18)F-FDGPET-CT标准化摄取值的影响  

Influence of renal function for standard uptake value in ^(18)F-FDG PET-CT of esophageal cancer

作　　者：李伟[1] 卢斌贵[1] 李建生[1] 汤日杰[1] 

机构地区：[1]广州医科大学附属肿瘤医院放射科,广东广州510095

出　　处：《中国中西医结合影像学杂志》2014年第6期610-612,F0003,共4页Chinese Imaging Journal of Integrated Traditional and Western Medicine

摘　　要：目的:分析肾功能改变对于食管癌患者和健康体检者18 F-FDG PET-CT标准化摄取值(standard uptake value,SUV)的影响。方法:行18F-FDG PET-CT检查的64例食管癌患者分别记录臀大肌和食管癌病灶的SUV(肌SUV和食管癌SUV);44例健康体检者分别记录臀大肌和食管的SUV(肌SUV和食管SUV)。食管癌患者和体检者均根据血Cr水平分别分为肾功能正常组和肾功能减低组。分别比较食管癌2组在肌SUV及食管癌SUV方面,体检者2组在肌SUV及食管SUV方面,差异是否有统计学意义。结果:食管癌患者中肾功能正常组与肾功能减低组的肌SUV(0.627±0.130、0.722±0.137)差异有统计学意义;体检者中肾功能正常组与肾功能减低组的肌SUV(0.654±0.145、0.794±0.229)、食管SUV(0.764±0.396、1.044±0.499),差异均有统计学意义。而食管癌患者中肾功能正常组与肾功能减低组的食管癌SUV(7.189±2.235、7.559±2.609)差异无统计学意义。结论:肾功能损害主要影响18F-FDG PET-CT人体本底SUV,对于食管癌病灶的SUV无显著影响。Objective：To study the influence of renal function changes for standard uptake value （SUV） in ^18F-FDG PET-CT of patients with esophageal carcinoma and healthy volunteers. Methods：64 cases with esophageal cancer underwent ^18 F-FDG PET- CT examination,and the SUV of gluteus maximus and esophageal carcinoma were recorded and named muscle SUV and cancer SUV. The SUV of gluteus maximus and esophagus in 44 volunteers were recorded and named muscle SUV and esophagus SUV. According to the level of blood Cr,patients and volunteers were divided into normal renal function group and renal dysfunction group respectively. Comparison were made in these two groups in terms of muscle SUV and cancer SUV in petients and muscle SUV and esophagus SUV in volunteers. Results： There were significant differences in muscle SUV （0. 627 ± 0. 130, 0. 722±0. 137） between 2 groups in patients and in muscle SUV （0. 654±0. 145,0. 794±0. 229） and esophagus SUV （0. 764± 0. 396,1. 044±0. 499） between 2 groups of volunteers. While there was no significant difference between 2 groups of patients in cancer SUV （7. 189 ±2. 235,7. 559 ± 2. 609）. Conclusion：Renal damage can effect the body＇s bottom SUV of ^18 F-FDG PET-CT and has no significant effect on esophageal cancer SUV.

关 键 词：氟脱氧葡萄糖F18 食管肿瘤 正电子发射断层显像术 肾功能不全 

分 类 号：R735.1[医药卫生—肿瘤] R730.44[医药卫生—临床医学]