抗菌肽LL-37与胃肠道疾病的研究进展  

Antimicrobial peptide LL-37 and gastrointestinal diseases

作　　者：郭方方[1,2] 房静远[1,2] 

机构地区：[1]上海交通大学医学院附属仁济医院胃肠和肝病科 [2]上海市消化疾病研究所,上海市200001

出　　处：《世界华人消化杂志》2014年第35期5454-5459,共6页World Chinese Journal of Digestology

摘　　要：抗菌肽(antimicrobial peptides,AMPs)是机体天然免疫的重要组成部分.内源性抗菌肽cathelicidins为存在于哺乳动物中的一类抗菌肽,而LL-37是目前发现的唯一一类存在于人体的cathelicidins家族抗菌肽,也在抗炎、抗肿瘤及组织修复等方面发挥着重要的调控作用.越来越多的研究表明LL-37与多种消化系疾病有关,其在消化系疾病诊断和治疗中的应用也日益受到关注.本文就LL-37的结构、生物学活性、与消化系疾病的关系及研究进展作一综述.Host defense antimicrobial peptides are key components of the human innate immunity that plays an indispensable role in human health. Cathelicidins are a family of antimicrobial peptides in mammals. LL-37, the only cathelicidin described so far in humans, plays a critical role in host defense against pathogen invasion, as well as regulating the functions of anti-inflammation, anti-tumorigenesis and tissue repair. Emerging evidence suggests that LL-37 is related to several kinds of gastrointestinal diseases, and its application to the diagnosis and treatment of gastrointestinal diseases has become a growing concern. This review aims to elucidate the structure and biological activity of LL-37 and discuss the recent progress in understanding the relationship between LL-37 and gastrointestinal diseases.

关 键 词：抗菌肽 LL-37 胃肠道疾病 

分 类 号：R57[医药卫生—消化系统]