hOGG1 Ser326Cys基因多态性与食管癌相关性的Meta分析  

A Meta-analysis of associationbetween h OGG1 Ser326cys polymorphism and esophagealcarcinoma

作　　者：李小林[1] 余倩[2] 欧文静[3] 范巧未 张学彦[1] 

机构地区：[1]哈尔滨医科大学附属第二医院消化内科,黑龙江省哈尔滨市150086 [2]哈尔滨医科大学附属第二医院地方病科,黑龙江省哈尔滨市150086 [3]哈尔滨医科大学公共卫生学院流行病学教研室,黑龙江省哈尔滨市150086

出　　处：《世界华人消化杂志》2014年第35期5501-5509,共9页World Chinese Journal of Digestology

摘　　要：目的:本研究采用Meta分析旨在更好地探讨人8-羟基鸟嘌呤糖苷酶(human 8-oxoguanine glycosylase,h OGG1)Ser326Cys多态性与食管癌易感性之间的关系.方法:使用中国生物医学文献数据库(CBM)、中国期刊全文数据库(C N K I)、万方数据库(Wan Fang DATA)、中文科技期刊全文数据库维普(VIP)、Medline、Pub Med、Academic Search Premier(ASP)等数据库检索关于h OGG1 Ser326Cys多态性与食管癌相关性的文献,使用OR值及95%可信区间评估相关度,使用Stata/SE 11.0软件进行统计分析.结果:14项病例-对照研究,包括2693例食管癌患者和4027名正常对照个体被纳入当前的Meta分析.我们发现h OGG1 Ser326Cys多态性与食管癌存在相关性.隐性模型C/C v s C/S+S/S:O R=1.26,95%C I:1.08-1.48;共显性模型C/C vs S/S:OR=1.25,95%CI:1.05-1.49.在亚组分析中显示:在隐性模型(C/C vs C/S+S/S)和共显性模型(C/C vs S/S)中,亚洲人群、鳞癌患者、以随机人群为来源的研究及以血液为DNA来源的研究中,h OGG1 Ser326Cys多态性可增加食管癌的易感性.结论:本研究显示h OGG1 Ser326Cys多态性与食管癌易感性之间存在相关性,Cys326基因型能增加食管癌发病风险.但以上结论仍需要大样本研究进行验证.AIM： To explore the association between the human 8-oxoguanine glycosylase （hOGG1） Ser326Cys polymorphism and esophageal carcinoma. METHODS： Databases, including CBM, CNKI, WanFang, VIP, Medline, Pubmed, and ASP were searched to identify studies assessing the association between the hOGG1 Ser326Cys polymorphism and esophageal carcinoma. Odds ratios （ORs） with 95% confidence intervals （CIs） were used to assess the strength of the association. Stata/SE 11.0 software was used for statistical analysis. RESULTS： Fourteen studies involving 2693 cases and 4027 controls were included. The hOGG1 Ser326Cys polymorphism was associated with esophageal carcinoma （recessive model C/C vs C/S＋S/S： OR = 1.26, 95%CI： 1.08-1.48; co-dominant model C/C vs S/S： OR = 1.25, 95%CI： 1.05-1.49）. In subgroup analyses, it was found that hOGG1 Ser326Cys polymorphism might increase the susceptibility to esophageal carcinoma in Asian populations, squamous cell carcinoma, and population- and tissue-based studies. CONCLUSION： This study suggested that the hOGG1 Ser326Cys polymorphism has relevance to esophageal carcinoma. Cys326 may increase the susceptibility to esophageal carcinoma. However, the above conclusion still needs validation by large sample studies.

关 键 词：食管癌 人8-羟基鸟嘌呤糖苷酶 多态性 易感性 META分析 

分 类 号：R735.1[医药卫生—肿瘤]