肠道菌群与大肠癌发病相关性的研究进展  

Gut microbiome and risk for colorectal cancer

作　　者：熊一白 朱惠蓉[1] 程悦蕾[1] 余志红[2] 柴妮[1] 

机构地区：[1]上海中医药大学附属曙光医院肿瘤科,上海市200021 [2]上海中医药大学附属曙光医院医务处,上海市200021

出　　处：《世界华人消化杂志》2014年第36期5653-5658,共6页World Chinese Journal of Digestology

基　　金：上海市中医药事业发展三年行动计划(重大研究)基金资助项目;No.ZYSNXD-CC-ZDYJ048;Three-year Action Plan to Promote Shanghai Traditional Chinese Medicine;No.ZYSNXD-CCZDYJ048

摘　　要：现在,对于大肠癌的诱因及病理机制还没有建立起来,而近年随着微生物学的发展,越来越多的证据表明在大肠癌中微生物导致的炎性因子的重要性.本综述主要讨论四种消化系微生物和大肠癌的关系,大肠埃希菌、幽门螺杆菌、脆弱类杆菌、牛链球菌.对于每种微生物,本综述都详细讨论了其可能致癌的机制及流行病学证据.The cause and pathogenesis of colorectal cancer are still not completely understood. The development of microbiology in recent years has increasingly provided more evidence for the importance of infectious agents in colorectal cancer. This review highlights investigations of four agents in relation to colorectal cancer： Escherichia coli, Helicobacter pylori, Bacterooides fragilis, and Streptococcus bovis. The possible mechanisms of carcinogenesis for each of these agents and epidemiologic evidence are discussed.

关 键 词：结肠癌 直肠癌 消化系菌群 

分 类 号：R735.34[医药卫生—肿瘤]