HIF-1α、COX-2在疣状胃炎患者胃黏膜组织中的表达及临床意义  

HIF-1α and COX-2 expression in varioliform gastritis

作　　者：吴县斌[1] 苏东星[1] 潘志刚[1] 陆才金[1] 陈庆洲[1] 战廷正[2] 

机构地区：[1]南宁市第二人民医院消化内科,广西壮族自治区南宁市530031 [2]广西医科大学寄生虫教研室,广西壮族自治区南宁市530021

出　　处：《世界华人消化杂志》2014年第36期5680-5683,共4页World Chinese Journal of Digestology

摘　　要：目的:研究低氧诱导因子-1α(hypoxia-inducible factor-1α,HIF-1α)、环氧化酶-2(cyclooxygena se-2,COX-2)在疣状胃炎患者胃黏膜组织中的表达情况及临床意义.方法:采用免疫组织化学的方法检测HIF-1α、C O X-2在成熟型疣状胃炎标本,未成熟型疣状胃炎标本及慢性浅表性胃炎标本中的表达情况.结果:慢性浅表性胃炎、未成熟型疣状胃炎及成熟型疣状胃炎标本中的HIF-1α和COX-2阳性表达率均具有统计学意义(P<0.05),且疣状胃炎标本中HIF-1α、COX-2阳性表达率显著性高于慢性浅表性胃炎标本(42.5%vs18.2%,χ2=12.777,P<0.05;46.4%vs 13.0%,χ2=23.991,P<0.05).结论:HIF-1α与COX-2在疣状胃炎标本中呈高表达.AIM： To examine the expression of hypoxia-inducible factor-1α （HIF-1α） and cyclooxygenase-2 （COX-2） in varioliform gastritis. METHODS： The expression of HIF-1α and COX-2 in varioliform gastritis specimens and chronic superficial gastritis specimens was detected by immunohistochemistry. RESULTS： Significant expression of HIF-1α and COX-2 was detected in chronic superficial gastritis and immature and mature verrucous gastritis （P 〈 0.05）. The positive rates of HIF-1α and COX-2 expression were significantly higher in varioliform gastritis than in chronic superficial gastritis （42.5% vs 18.2%, χ^2 = 12.777, P 〈 0.05; 46.4% vs 13.0%, χ^2 = 23.991, P 〈 0.05）. CONCLUSION： High expression of HIF-1α and COX-2 was detected in varioliform gastritis.

关 键 词：疣状胃炎 低氧诱导因子-1Α 环氧化酶-2 免疫组织化学 

分 类 号：R573.3[医药卫生—消化系统]