老年消化系肿瘤贫血患者血红蛋白和红细胞体积及细胞免疫的临床意义  

Changes in hemoglobin, red blood cell volume and cellular immunity in elderly patients with gastrointestinal tumors and anemia

作　　者：杨华强[1] 张荣环[2] 李红[1] 李玉玲[1] 覃骏[1] 鲍红霞[1] 

机构地区：[1]湖北医药学院附属人民医院血液科,湖北省十堰市442000 [2]十堰市妇幼保健院妇保科,湖北省十堰市442000

出　　处：《世界华人消化杂志》2014年第36期5737-5741,共5页World Chinese Journal of Digestology

基　　金：湖北省教育厅科学技术研究计划重点项目基金资助项目;No.D20142104~~

摘　　要：目的:观察老年消化系肿瘤贫血患者血红蛋白、红细胞体积、CD3、CD4、CD8、CD4/CD8和自然杀伤(natural killer,NK)细胞的变化并探究其临床意义.方法:将湖北医药学院附属人民医院收治的62例老年消化系肿瘤患者作为肿瘤组,按照是否贫血分为肿瘤贫血组和肿瘤非贫血组,并选择同时期健康体检老人30例作为对照组,使用血液分析仪和流式细胞仪对消化系肿瘤患者的血红蛋白、红细胞体积、CD3、CD4、CD8、CD4/CD8和NK细胞进行检测,并与对照组进行比较.结果:在肿瘤组患者中,红细胞体积分布宽度、CD8均高于对照组患者,组间差异有统计学意义(P<0.05);在血红蛋白数、CD3、CD4、CD4/CD8和NK细胞等指标上,肿瘤组患者均明显低于对照组患者,组间差异均有显著统计学意义(P<0.01);在肿瘤贫血组患者中,红细胞体积分布宽度、CD8均明显高于肿瘤非贫血组患者,组间差异具有显著统计学意义(P<0.01);在血红蛋白数、CD3、CD4、CD4/CD8和NK细胞等指标上,肿瘤贫血组患者均明显低于肿瘤非贫血组患者,组间差异均具有显著统计学意义(P<0.01).结论:老年消化系肿瘤患者发生贫血的几率高于正常健康人群,老年消化系肿瘤患者的细胞免疫功能低于正常人群,合并贫血时,患者免疫功能会进一步下降,可以为老年消化系肿瘤的诊疗提供参考.AIM： To assess the changes in hemoglobin, red blood cell volume, CD3＋, CD4＋, CD8＋, CD4＋/CD8＋ and natural killer （NK） cells in elderly patients with digestive system tumors and anemia. METHODS： Sixty-two elderly patients with gastrointestinal cancer treated at our hospital were divided into either an anemia group or a non-anemic cancer group according to whether they had anemia. Thirty healthy elderly people served as a control group. Hemoglobin, red blood cell volume, CD3＋, CD4＋, CD8＋, CD4＋/CD8＋ and NK cells were detected using a blood analyzer and flow cytometer and compared between different groups. RESULTS： Red blood cell distribution width （RDW） and CD8^＋ cells were significantly higher in patients with gastrointestinal cancer than in controls （P 〈 0.05）, while hemoglobin count, CD3^＋, CD4^＋, CD4^＋/CD8^＋ and NK cells were significantly lower in patients with gastrointestinal cancer （P 〈 0.01）. RDW and CD8^＋ cells were significantly higher in cancer patients with anemia than in those without anemia （P 〈 0.01）, while hemoglobin, CD3^＋, CD4^＋, CD4^＋/CD8^＋ and NK cells were significantly lower in cancer patients with anemia than in those without anemia （P 〈 0.01）. CONCLUSION： The incidence of anemia in elderly patients with gastrointestinal cancer is higher than that in healthy people. Cellular immunity is lower in elderly patients with gastrointestinal cancer than in the normal population. Concomitance with anemia can result in a further decline in cellular immune function.

关 键 词：消化系肿瘤 贫血 免疫 

分 类 号：R735[医药卫生—肿瘤]