4,6-二甲基-2-甲磺酰基嘧啶的合成  

Synthesis of 4,6-Dimethyl-2-methanesulfonylpyrimidine

作　　者：邢磊[1] 周启璠 陈国良[1] 

机构地区：[1]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016

出　　处：《精细化工中间体》2014年第6期35-36,39,共3页Fine Chemical Intermediates

摘　　要：以硫脲为原料,经碳酸二甲酯甲基化,乙酰丙酮环合,再用过氧化氢氧化得到4,6-二甲基-2-甲磺酰基嘧啶,3步反应的总收率为71.0%。目标化合物结构经GC-MS、1H NMR确证。4,6-Dimethyl-2-methanesulfonylpyrimidine i biologically active compounds. The target compound was p via methylation with dimethyl carbonate, condensation wi s an important intermediate for the synthesis of many repared in overall yield of 71.0% starting from thiourea th acetylacetone, and oxidation by hydrogen peroxide. The structure of target compound was characterized by 1H NMR and GC-MS spectra.

关 键 词：4 6-二甲基-2-甲磺酰基嘧啶 硫脲 乙酰丙酮 

分 类 号：TQ463[化学工程—制药化工] O624.32[理学—有机化学]