松花粉提取物抗炎功效及安全性的研究  

The Anti-inflammatory Effect and Safety of Pine Pollen Extract

作　　者：王桐 于建伟 杨长军 鞠东 金文[2] 衣洁菡 

机构地区：[1]烟台新时代健康产业有限公司,山东烟台264006 [2]中国医学科学院药用植物研究所,北京100094

出　　处：《食品研究与开发》2014年第23期21-24,共4页Food Research and Development

摘　　要：主要开展了松花粉提取物抗炎作用及服用安全性的研究。通过小鼠耳肿胀模型和小鼠扭体实验,记录肿胀抑制率和小鼠扭体次数和潜伏期,验证松花粉提取物的抗炎、镇痛作用;通过急性毒性实验,了解松花粉提取物的服用安全性。结果表明:松花粉提取物各剂量组的肿胀抑制率分别为:低剂量组41.16%、中剂量组26.26%和高剂量组33.65%,各剂量组的白细胞和淋巴细胞均未见明显改变。中、高剂量组扭体次数(p<0.01)分别减少了63.8%和66.3%,扭体出现时间(p<0.01)也显著延长85.1%、91.0%;急性毒性试验中各组动物均未发现有明显中毒反应,也无一例死亡,按急性毒性分级,松花粉提取物应属实际无毒物质。The anti-inflammatory effects and safety of pine pollen extract was studied in this paper. By the mouse ear swelling model and acetic acid stretching experiment, the inhibition rate of swelling and the writhing times of the latency were investigated. The effect of anti-inflammatory and analgesic of pine pollen extract were summarized. The safety effects of taking pine pollen extract was studied by acute toxicity test. The results indicated that pine pollen extract in each dose group of swelling inhibition rates were 41.16 %,26.26 % and 33.65%from low dose group to high dosage group, and leukocytes and lymphocytes in each dose group showed no obvious change. In the middle and high dose group, the writhing frequency （p〈0.01） were reduced by 63.8%and 66.3%, time of writhing （p〈0.01） significantly increased 85.1%and 91%also. Obvious toxic reaction and death were not found in acute toxicity test. According to acute toxicity grading , pine pollen extract is a non-toxic substances actually.

关 键 词：松花粉 抗炎 耳肿胀 扭体实验 急性毒性试验 

分 类 号：TS201.2[轻工技术与工程—食品科学]