肿瘤标志物及生化指标联合检测在良恶性胸腹腔积液诊断中的作用  

Effect of Combined Detection of Tumor Markers and Biochemical Markers in the Diagnosis of Benign and Malignant Pleural and Peritoneal Effusion

作　　者：袁晃堆[1] 肖燕青[2] 

机构地区：[1]广东省东莞市妇幼保健院,广东东莞523000 [2]广东省广州市暨南大学附属第一医院,广东广州510630

出　　处：《中外医疗》2014年第32期26-27,29,共3页China & Foreign Medical Treatment

摘　　要：目的探讨良恶性胸腔积液生化指标及肿瘤标志物联检作用。方法选取胸腹腔积液患者100例,采用生化指标及肿瘤标志物联合检测,其中良性组60例,恶性组40例。采用罗氏Cobas e411全自动电化学发光分析仪及配套设施实施检测操作,入院治疗前,对患者空腹静脉血和胸腹腔积液进行抽取,离心后,将血清和上清液取出完成相关测定。结果相较良性组病例,恶性组CYFRA21-1、CEA、CA724、CA125浓度均居较高水平,分别为(124.8±26.4)ng/m L,(166.9±54.3)ng/m L,(39.5±14.8)U/m L,(1205.7±174.2)U/m L。差异有统计学意义(P<0.05)。CYFRA21-1、CEA、CA724、CA125联检相较单项有更高特异度和敏感度(P<0.05)。结论胸腹腔积液性质鉴别诊断中,对血清与胸腹腔积液中的CYFRA21-1、CEA、CA724、CA125检测,有较高临床价值,特别是4种指标联合,敏感度和特异度居更高水平,LDH、GLU、FT生化指标可辅助诊断,值得临床引起重视,并广泛推广应用。Objective To investigate the value of combined detection of benign and malignant pleural effusion biochemical index and tumor markers. Methods 100 patients with pleural and peritoneal effusion were selected. Combined detection of biochemical indexes and tumor markers were used. There were 60 patients in the benign group, and 40 cases in the malignant group. Roche Cobas e411 automatic electrochemiluminescence analyzer and supporting facilities were used to implement the inspection operation. Before the hospitalized treatment, the fasting venous blood and the pleural and peritoneal effusion of the patients were extracted, and after centrifugating, the serum and liquid supernatant were taken out and the related detection was completed. Results The level of CYFRA21-1, CEA, CA724, CA125 of the malignant group was（124.8±26.4） ng/m L,（166.9±54.3） ng/m L,（39.5±14.8）U/m L,（1205.7 ±174.2） U/m L, respectively, higher than that of the benign group, respectively with statistical differences（P〈 0.05）.And the combined detection of CYFRA21-1, CEA, CA724, CA125 had higher specificity and sensitivity than single detection（P〈0.05）. Conclusion In the differential diagnosis of benign and malignant pleural and peritoneal effusion, the detection of CYFRA21-1, CEA, CA724, CA125 in serum and pleural and peritoneal effusion has high clinical value, especially the combined detection of the four indexes has higher sensitivity and specificity, and LDH, GLU, FT biochemical indicators can be used as the auxiliary diagnosis, these are worthy of clinical attention and wide application and promotion.

关 键 词：肿瘤标志物 生化指标 联合检测 良恶性胸腹腔积液 诊断作用 

分 类 号：R730.4[医药卫生—肿瘤]