复方甘草酸苷预防结核药物性肝炎序贯治疗的临床研究  

Clinical Study of Compound Glycyrrhizin in the Sequentially Preventive Treatment of Antituberculosis Drug-induced Hepatitis

作　　者：张子胜[1] 

机构地区：[1]福建省疾病预防控制中心第二门诊部,福建福州350007

出　　处：《中外医疗》2014年第34期11-12,共2页China & Foreign Medical Treatment

摘　　要：目的探讨复方甘草酸苷预防结核药物性肝炎序贯治疗的临床效果。方法选取2011年8月—2014年2月期间在该中心诊治的结核药物性肝炎患者140例,根据随机抽签法分为治疗组与对照组各70例,对照组给予常规治疗,在此基础上治疗组加用复方甘草酸苷预防序贯治疗,都治疗3个月。结果治疗后治疗组与对照组的有效率分别为97.1%和84.3%,治疗组总有效率明显高于对照组(P<0.05)。两组治疗后血清ALT与AST值明显下降,与治疗前对比差异有统计学意义(P<0.05),同时治疗后治疗组的血清ALT与AST值明显低于对照组(P<0.05)。结论复方甘草酸苷预防结核药物性肝炎序贯治疗能有效发挥肝功能的保护作用,提高预后疗效,值得推广应用。Objective To investigate the clinical effect of compound glycyrrhizin in the sequentially preventive treatment of antitu- bereulosis drug-induced hepatitis. Methods 140 cases with antituberculosis drug-induced hepatitis diagnosed and treated in our center from August 2011 to Febrtiary 2014 were selected and randomly divided into the treatment group and the control group with 70 cases in each. The control group were given the conventional treatment, and the treatment group were given compound glycyrrhizin sequentially preventive treatment based on the treatment given to the control group. Both groups were treated for 3 months. Results After treatment, the effective rate of the treatment group and the control group was 97.1%, 84.3%, respectively, the total efficiency of the treatment group was significantly higher （P〈0.05）. After treatment, the serum ALT and AST values of both groups decreased significantly compared with those before treatment with significant difference （P〈0.05）, and the serum ALT and AST values of the treatment group were significantly lower than those of the control group（P〈0.05）. Conclusion Compound glycyrrhizin in the sequentially preventive treatment of antituberculosis drug-induced hepatitis can effectively protect the liver function and improve the prognosis, which should be widely applied.

关 键 词：结核药物性肝炎 复方甘草酸苷 肝功能 

分 类 号：R575.1[医药卫生—消化系统]