血清TK1和CA15-3含量在乳腺癌患者中的变化及临床价值  

The Changes and Clinical Values of Serum TK1 and CA15-3 Levels in Patients with Breast Cancer

作　　者：段春霞[1] 郝艳梅[1] 陈丽霞[1] 

机构地区：[1]包头医学院第一附属医院肿瘤内科,内蒙古包头014010

出　　处：《中外医疗》2014年第35期1-2,5,共3页China & Foreign Medical Treatment

摘　　要：目的探讨检测血清TK1和CA15-3在乳腺肿瘤诊断、临床分期及预后中的临床价值。方法采用酶免疫点印迹化学发光法检测2011年1月—2013年12月该院收治的100例乳腺癌患者、80例乳腺良性疾病、80例正常对照者血清TK1水平,同时采用罗氏电化学发光分析仪检测CA15-3含量。比较乳腺癌患者与乳腺良性疾病及对照组的TK1和CA15-3水平的差异,分析乳腺癌组患者血清CA15-3和TK1水平与淋巴结转移、术后复发及临床分期的关系。结果乳腺癌组TK1和CA15-3含量明显高于乳腺的良性肿瘤以及健康人群组(P<0.01),乳腺的良性肿瘤组与健康人群组差异无统计学意义(P>0.05)。联合检测CA15-3和TK1能够提高诊断的灵敏度和特异性,血清TK1含量与乳腺癌分期相关,术后2年复发以及有淋巴结转移的患者中,TK1含量显著升高(P<0.05)。结论血清TK1可为乳腺癌预后判断及病情监测提供重要价值,与CA15-3联合检测能够提高乳腺癌诊断的检出率。Objective The study was carried out to determine the clinical value of serum TK1 and CA15-3 as tumor markers in the diagnosing, judging clinical stage and prognosis of breast tumor. Methods The levels of serum TK1 from 100 cases with breast cancer, 80 cases with benign breast disease and 80 normal controls were detected by molecularly imprinted chemiluminescence method. At the same time, the levels of the CA15-3 were detected by Roche 2010 Immunoassay System. The levels of TK1 and CA15-3 of the patients with breast cancer, patients benign breast disease and the control group were compared, and the correlation of serum TK1 and CA15-3 levels of breast cancer patients with lymph node metastasis, postoperative recurrence and the clinical stage was analyzed. Results The level of CA15-3 and TK1 in breast cancer group was significantly higher than that in benign breast tumor group and healthy group（P0.01）, while benign breast tumor group and healthy group had no significant difference（P0.05）. The sensitivity and specificity of the diagnosis were improved by the joint detection of CA15-3 and TK1. And the serum TK1 level is related to breast cancer staging; the TK1 levels increased significantly in the patients who had recurrence and lymph node metastasis two years after operation（P0.05）. Conclusion Serum TK1 is of great value in judging the prognosis and monitoring the condition of breast cancer, and the detection of serum TK1 combined with CA15-3 can improve the diagnosis rate of breast cancer.

关 键 词：胸苷激酶1 CA15-3 乳腺癌 临床价值 

分 类 号：R73[医药卫生—肿瘤]