脑功能网络核心节点及网络稳定性研究  

Research on hubs and stability of the brain functional network

作　　者：王祖力[1] 张艳[1] 

机构地区：[1]中国计量学院光学与电子科技学院,浙江杭州310018

出　　处：《中国计量学院学报》2014年第4期414-418,共5页Journal of China Jiliang University

摘　　要：采用偏相关的计算方法对大脑的正电子断层发射成像建立脑区间的功能连接网络,利用小世界网络中节点度和节点介数求出大脑网络中的核心节点并对应到解剖学结构中,通过随机攻击和对核心节点的目标攻击研究网络的稳定性.结果表明,大脑网络具有明显的小世界拓扑结构,拥有较高度和较大节点介数的节点为网络的核心节点,从而得出正常人大脑的核心节点主要分布在额叶和顶叶区域,通过随机攻击和对节点中心的目标攻击得出大脑网络具有较强的鲁棒性和脆弱性.Using the partial correlation calculation method, we established the brain functional network for position emission tomography （PET） imaging of the brain. Hubs in the brain functional network were deduced by the node degree and betweenness centrality and were corresponded to the anatomical structure. The network stability was tested by random attacks and targeted attacks on the hubs. The results show that the brain system has obvious topological property of small-world characteristics, and the regions with a higher node degree and larger betweenness centrality are the hubs of the brain functional network. So the hubs of a normal brain functional network are mainly distributed in the frontal and parietal lobes, and the brain functional network has robustness and fragility by random attacks and targeted attacks on the hubs.

关 键 词：正电子断层发射成像 偏相关 核心节点 鲁棒性 脆弱性 

分 类 号：R318[医药卫生—生物医学工程]