伽玛刀治疗颅底软骨肉瘤  

Gamma knife radiosurgery for skull base chondrosarcoma

作　　者：高德智[1] 罗斌[1] 孙时斌[1] 鲍恩萌[1] 刘鹏[1] 王美华[1] 潘剑[1] 刘阿力[1] 

机构地区：[1]首都医科大学北京市神经外科研究所伽玛刀中心,100050

出　　处：《中华神经外科杂志》2014年第12期1205-1208,共4页Chinese Journal of Neurosurgery

摘　　要：目的 探讨伽玛刀治疗颅底软骨肉瘤的临床效果.方法 回顾分析2007年10月至2013年12月6例软骨肉瘤患者资料,男5例,女1例;年龄28 ～ 65岁,平均45.6岁.所有患者均经手术病理证实为软骨肉瘤.其中间叶型软骨肉瘤1例,标准型软骨肉瘤5例.肿瘤体积4.7 ～62.4 cm^3,平均16.8 cm3.周边剂量10～ 14 Gy（平均13.3 Gy,中位13.5 Gy）,中心剂量26～31 Gy（平均29.1 Gy,中位28.6 Gy）,伽玛刀治疗后随访时间6～51个月（平均29.3个月,中位27.0个月）.结果 1例间叶型软骨肉瘤患者术后15个月死亡,1例术后27.0个月复发,再次行伽玛刀治疗,随访至今肿瘤控制良好.4例肿瘤控制良好,且无放射相关并发症出现.结论 伽玛刀作为颅底软骨肉瘤的术后辅助治疗安全且有效.Objective To assess outcomes after gamma knife radiosurgery for chondrosarcomas of the skull base.Methods Six patients （one female and five male） with skull base chondrosarcomas were reviewed who underwent gamma knife treatment between 2007 and 2013.The mean patient age was 45.6 years （range 28-65 years）.All patients were diagnosed as chondrosarcoma by histological confirmation.All patients had no radiation therapy experience.The mean tumor volume was 16.8 cm（range 4.7-62.4 cm） and mean/median margin dose was 13.3/13.5 Gy （range 10-14 Gy）,and the mean/median tumor maximum dose was 29.1/28.6 Gy（range 26-31 Gy）.The mean/median followed up time was 29.3/27.0 months （range 6-51 months）.Results One paitent who was diagnosisd as mesenchymal chondrosareoma dead at 15 months after gamma knife treatment because of tumor progression at 27 months,one patient underwent repeat gamma knife treatment,and the tumor progression free until now.Other 4 patient keep tumor progression free.No symptomatic adverse radiation effects occurred.Conclusion Stereotactic radiosurgery provide a benefit to patients as a adjuvant therapy for skull base chondrosarcoma.

关 键 词：立体定向放射外科 颅底软骨肉瘤 伽玛刀 放射治疗 

分 类 号：R739.41[医药卫生—肿瘤]