氟伐他汀对心肌梗死大鼠心室重构及MMP-9、MMP-10表达的影响  

Effect of Fluvastatin on Ventricular Remodeling and Expression of MMP-9 and MMP-10 in Acute Myocardial Infarction Rats

作　　者：王士凯 褚亚丽 徐娟娟 梁江久[2] 

机构地区：[1]宁阳县第一人民医院,山东省泰安市271400 [2]山东大学附属千佛山医院保健科,山东省济南市250014

出　　处：《中国动脉硬化杂志》2014年第9期917-920,共4页Chinese Journal of Arteriosclerosis

基　　金：山东省自然科学基金(ZR2010HM116)

摘　　要：目的研究氟伐他汀对心肌梗死(AMI)大鼠基质金属蛋白酶(MMP-9、MMP-10)表达的影响,以探讨他汀类药物改善急性心肌梗死后心室重构的机制。方法 Wistar雄性大鼠随机分为假手术组、心肌梗死组、氟伐他汀组各12只,后两组均建立左冠状动脉前降支心肌梗死模型,氟伐他汀组于制模成功后予氟伐他汀灌胃6周,测左心室血流动力学参数、左心室重构指数及MMP-9、MMP-10表达的变化。结果与假手术组比较,心肌梗死组和氟伐他汀组大鼠左心室收缩压、左心室压最大上升速率及左心室压最大下降速率均明显下降(P<0.05),且心肌梗死组较氟伐他汀组下降更明显(P<0.05)。与假手术组比较,心肌梗死组和氟伐他汀组左心室舒张期末内径(LVEDD)和左心室收缩期末内径(LVESD)均显著增加,左心室射血分数(LVEF)均显著降低(P<0.05),心脏组织MMP-9、MMP-10表达明显增强(P<0.01);与心肌梗死组相比,氟伐他汀组LVEDD、左心室质量指数(LVMI)均降低,心脏组织MMP-9、MMP-10表达明显降低(P<0.01),LVEF显著增加(P<0.05)。结论氟伐他汀能逆转心室重构,其作用机制可能与抑制MMP-9、MMP-10的表达有关。Aim To study the effect of fluvastatin on cardiac remodeling and cardiac function,and to investigate the effect of matrix metalloproteinase-9（MMP-9） and MMP-10. Methods 36 Wistar rats were randomly divided into acute myocardial infarction（AMI） group,AMI ＋ fluvastatin group and the sham-operated group. AMI was established by ligation of the anterior descending coronary artery in rats,fluvastatin was fed to AMI ＋ fluvastatin group by 20 mg /（ kg·d） for 6 weeks. After 6 weeks treatment,then the hemodynamic parameters and mass index of left ventricular and the expression of MMP-9 and MMP-10 were detected. Results Compared with the sham-operated group,left ventricular systolic pressure（LVSP） and the maximal rate of rise and fall（ ± dp /dtmax） of left ventricular pressure in the AMI group and AMI ＋ fluvastatin group were all decreased（ P 〈 0. 05）,moreover,these indexes decreased significantly in AMI group than those in AMI ＋ fluvastatin group（P 〈 0. 05）. Compared with the sham-operated group,left ventricular end-diastolic diameter（LVEDD）,left ventricular end systolic diameter（ LVESD）,left ventricular mass index（ LVMI）,MMP-9,MMP-10 were significantly increased in the AMI group and AMI ＋ fluvastatin group; moreover,these indexes decreased in AMI ＋ fluvastatin group than those in AMI group（P 〈 0. 05）. Conclusion Fluvastatin could prevent the cardiac remodeling,the mechanisms may be by reducing the levels of MMP-9 and MMP-10.

关 键 词：心肌梗死 心室重构 氟伐他汀 基质金属蛋白酶9 基质金属蛋白酶10 

分 类 号：R363[医药卫生—病理学]