动脉粥样硬化中巨噬细胞增殖调控的研究进展  

Research Progress of Regulation of Macrophage Proliferation in Atherosclerosis

作　　者：张欣[1] 张晓卉[1] 尹新华[1] 

机构地区：[1]哈尔滨医科大学附属第一医院心血管内科,黑龙江省哈尔滨市150001

出　　处：《中国动脉硬化杂志》2014年第9期961-964,共4页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81370319)

摘　　要：巨噬细胞是机体免疫系统的重要组成部分,在动脉粥样硬化及相关的心血管疾病中发挥至关重要的作用。传统观点认为巨噬细胞来源于血液单核吞噬系统并不可再生,但新近研究表明组织内巨噬细胞具有增殖能力并发挥关键作用。目前已知细胞周期调节物、骨髓生长因子和氧化型低密度脂蛋白与动脉粥样硬化中巨噬细胞增殖关系密切。本文就动脉粥样硬化中巨噬细胞增殖调控加以综述。Macrophage,an important component of the immune system,plays a crucial role in atherosclerosis and related cardiovascular diseases. Conventional wisdom holds that macrophages are derived from blood mononuclear phagocytic system and not renewable,but recent studies have shown that tissue macrophage can proliferate and has played a key role. Cell cycle regulators,bone growth factors and oxidized low density lipoprotein are closely related with macrophages in atherosclerosis. This article briefly reviews regulation of macrophage proliferation in atherosclerosis.

关 键 词：动脉粥样硬化 巨噬细胞 细胞增殖 

分 类 号：R363[医药卫生—病理学]