巨噬细胞增殖和凋亡与动脉粥样硬化  

Macrophage Proliferation and Apoptosis on Atherosclerosis

作　　者：陈孔[1,2] 曾高峰[2] 唐朝克[1] 

机构地区：[1]南华大学心血管疾病研究所动脉硬化学湖南省重点实验室生命科学研究中心 [2]南华大学附属第二医院心内科,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2014年第9期965-969,共5页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金资助项目(81170278;8107022;81370377);湖南省自然科学衡阳联合基金(10JJ9019)

摘　　要：动脉粥样硬化(As)是一种由动脉壁脂质沉积所引发的一种病理生理过程,与巨噬细胞介导的慢性炎性反应高度相关。As早期,巨噬细胞通过吞噬作用清除斑块中修饰脂蛋白、细胞碎片和死亡细胞,限制斑块生长。随着病程进展,斑块中巨噬细胞凋亡增多且清除功能下降,引起继发性细胞坏死和炎性反应,促成不稳定斑块形成。巨噬细胞增殖和凋亡与As发生发展密切相关。本文主要针对巨噬细胞增殖和凋亡对As发生发展的影响做一综述,为As防治提供理论依据。Atherosclerosis（As） is a pathological and physiological process triggered by lipid deposition in arterial wall,and is highly correlated with chronic inflammatory reaction mediated by macrophages. In early stage of atherosclerosis,macrophage limits disease progression by phagocytizing modified lipoproteins,cellular debris and dead cells. As the disease progresses,macrophages apoptosis increases and efferocytosis defective causes the secondary necrosis and inflammatory reaction,thus promotes the formation of unstable plaques. Macrophage proliferation and apoptosis are closely related to atherosclerosis. Therefore,this article focuses on macrophage proliferation and apoptosis on atherosclerosis,providing the theoretical basis for atherosclerosis prevention and control.

关 键 词：巨噬细胞增殖 细胞凋亡 动脉粥样硬化 

分 类 号：R363[医药卫生—病理学]