肱动脉内皮功能与颅内动脉粥样硬化性狭窄的相关性  

Research on Brachial Artery Endothelial Function and Intracranial Atherosclerotic Stenosis

作　　者：刘康[1] 黎红华[1] 向慧娟[2] 

机构地区：[1]广州军区武汉总医院神经内科,湖北省武汉市430077 [2]广州军区武汉总医院超声影像科,湖北省武汉市430077

出　　处：《中国动脉硬化杂志》2014年第11期1152-1156,共5页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨缺血性脑血管病患者肱动脉血流介导的血管扩张和非内皮依赖性血管舒张与颅内动脉狭窄的相关性。方法将67例缺血性脑血管病患者根据有无颅内血管狭窄分为两组,颅内血管狭窄组和对照组。对两组患者一般资料及肱动脉血流介导的血管扩张功能、非内皮依赖性血管舒张功能进行对比分析,并进一步分析肱动脉血流介导的血管扩张功能、非内皮依赖性血管舒张功能与颅内血管狭窄数量的相关性。结果颅内动脉狭窄组有50例,对照组有17例,年龄、肱动脉血流介导的血管扩张功能、非内皮依赖性血管舒张功能、高血压病、糖尿病、既往卒中或短暂性脑缺血发作史与颅内动脉硬化性狭窄相关,且肱动脉血流介导的血管扩张功能(rs=-0.869,P=0.000)与非内皮依赖性血管舒张功能(rs=-0.490,P=0.000)分别与颅内血管狭窄的数量存在负相关关系。非条件Logistic回归分析得出肱动脉血流介导的血管扩张可作为评估颅内动脉硬化性狭窄的独立因素,以肱动脉血流介导的血管扩张功能值为2.95%时诊断颅内动脉硬化性狭窄的可能性最大。结论颅内动脉硬化性狭窄患者存在肱动脉血流介导的血管扩张功能的降低,且肱动脉血流介导的血管扩张功能可能对颅内血管狭窄有一定的预测价值。Aim To explore the correlation among flowmediated dilatation,nitroglycerinmediated dilatation of brachial artery and intracranial atherosclerotic stenosis in ischemic cerebrovascular disease patients. Methods According to the presence of intracranial vascular stenosis,67 patients with ischemic cerebrovascular disease are divided into two groups,intracranial vascular stenosis group and control group,of which general data,FMD,NMD are analyzed relatively. Then the relevance of FMD,NMD and the number of intracranial vascular stenosis is further analyzed. Results There are 50 patients in intracranial atherosclerotic stenosis group and 17 patients in control group. Intracranial atherosclerotic stenosis is related to age,FMD,NMD,Hypertension,Diabetes,history of previous stroke / TIA. And there is a negative relationship between FMD（ rs =- 0. 869,P = 0. 000 〈 0. 05）,NMD（ rs =- 0. 490,P = 0. 000 〈 0. 05） and the number of intracranial vascular stenosis. Unconditional logistic regression analysis shows that FMD can be used as an independent factor of evaluation of intracranial atherosclerotic stenosis,which could be the most likely diagnosis of intracranial vascular stenosis when it was 2. 95%. Conclusions FMD was low in patients with intracranial atherosclerotic stenosis,which may also has value in predicting the extent of intracranial vascular stenosis.

关 键 词：颅内血管狭窄 肱动脉血流介导的血管扩张 非内皮依赖性血管舒张 

分 类 号：R743.1[医药卫生—神经病学与精神病学]