CMYA5基因多态性与新疆维吾尔族精神分裂症的关联性研究  

The association between the Uygur patients with schizophrenia and CMYA5 polymorphism

作　　者：罗晓[1] 张丽丽[2] 韩书贤 安志国[1] 伊琦忠[1] 

机构地区：[1]新疆医科大学第一附属医院,乌鲁木齐830000 [2]河北省第六人民医院

出　　处：《中国神经精神疾病杂志》2014年第12期726-730,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：国家自然科学基金(编号:81360209);"973"计划子课题(编号:2007CB512301);"863"计划子课题(编号:2006AA02A-407);新疆维吾尔自治区自然科学基金(编号:2010211A51)

摘　　要：目的探讨心肌病相关基因5(cardiomyopathy associated 5,CMYA5)rs3828611位点基因多态性与新疆维吾尔族人群精神分裂症的关联性。方法通过Taq-man探针分型技术,对684例维吾尔族精神分裂症患者及678名维吾尔族正常对照的CMYA5基因rs3828611位点进行基因分型,采用阳性与阴性症状量表(positive and negative symptoms scale,PANSS)评估患者症状。结果患者组与对照组间,rs3828611位点基因型与等位基因频率分布差异均无统计学意义(P>0.05);患者组男性与对照组男性、患者组女性与对照组女性间rs3828611位点基因型与等位基因频率分布差异均无统计学意义(P>0.05);青少年发病的患者与青少年对照之间,以及成年发病的患者与成年对照间等位基因和基因型频率差异无统计学意义(P>0.05)。不同基因型患者之间PANSS量表评分差异无统计学意义(P>0.05)。结论 CMYA5基因rs3828611位点多态性与新疆维吾尔族精神分裂症无明显关联。Objective To investigate the association between Cardiomyopathy associated 5 （CMYA5） polymorphisms and schizophrenia in the Uygur Chinese population. Methods Taq-man assay was used to detect CMYA5 gene rs3828611 in 684 schizophrenia patients and 678 healthy controls from Chinese population. The positive and negative symptoms scale （PANSS） was used to evaluate patients’symptoms. Results Neither the genotype nor the allele frequencies of rs3828611 was significantly different between the patients and the controls （P〉0.05）. The differences were not significant in either each gender subgroup or in each age （teenager and adult） subgroup （P〉0.05）. The total score and the sub scores of PANSS were not significantly different among patients with different genotype groups （P〉0.05）. Conclusions There is no association between CMYA5 rs3828611and schizophrenia in the Uygur Chinese population.

关 键 词：精神分裂症 心肌病相关基因5 rs3828611位点 单核苷酸多态性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]