PTEN和mTOR在食管鳞癌组织中的表达及意义  

Expression of PTEN and m TOR in esophageal squamous carcinoma tissues and their significance

作　　者：鲁建军[1] 雷艺炎[1] 潘游[1] 冯沿芬[2] 

机构地区：[1]中山大学附属第一医院胸外科,广东广州510080 [2]中山大学肿瘤防治中心病理科,广东广州510060

出　　处：《解剖学研究》2014年第6期447-450,共4页Anatomy Research

基　　金：广东省科技计划项目(2011B080701095)

摘　　要：目的观察食管鳞癌组织中PTEN与m TOR的表达,探讨其与临床病理特征的关系。方法应用免疫组化染色检测148例食管鳞癌组织、癌旁组织及其正常食管组织中PTEN和m TOR表达,分析其与常见临床病理特征的关系。结果PTEN在癌组织中阳性表达率为43.9%,癌旁组织为67.6%,而正常组织为93.2%,食管癌组织中PTEN表达率均低于癌旁组织及正常食管黏膜组织,差异有统计学意义(P<0.05);m TOR在癌组织中阳性表达率为85.8%,癌旁组织为35.1%,而正常组织为3.4%,食管癌组织中m TOR表达明显高于癌旁组织及正常食管组织,差异有统计学意义(P<0.05)。PTEN的表达与m TOR的表达强度呈负相关(P<0.05)。m TOR表达与性别、年龄、肿瘤长度差异无统计学意义(P>0.05),而与肿瘤浸润深度、肿瘤分化程度以及有无淋巴结转移上差异无统计学意义(P<0.05)。结论 m TOR信号通路的激活与PTEN的抑制,可能在食管鳞癌的发生发展中起重要的作用,PTEN低表达与m TOR高表达与肿瘤恶性程度有关,两者联合检测可能有助于预后的判断。Objective Observe the expression of PTEN and m TOR in esophageal squamous carcinoma tissues and explore their relationship with the pathological types. Methods The expressions of PTEN and m TOR were detected in 148 cases of esophageal squamous carcinoma, counterpart para-carcinoma and normal tissues by immunohistochemistry, analyzing their relevance with the clinical pathological features. Results There was significant differencein PTENamong esophageal squamous carcinoma tissues（43.9%）, counterpart para-carcinoma tissues（67.6%）, and normal tissues（93.2%）, decreased in esophageal squamous carcinoma（P 〈0.05）; while the expression of m TOR among theesophageal squamous carcinoma tissues（85.8%）,counterpart para-carcinoma tissues（35.1%）, and normal tissues（3.4%）, with statistical significance（P〈0.05）, and PTEN was strong negative correlation with m TOR. Further, there is no statistically significant difference between m TOR and sex, age and tumor length（P 〉0.05）, however, Statistical analysis showed a significant difference between m TOR andtumor infiltration depth degree, tumor differentiation and presence of lymph node metastasis（P〈0.05） respectively. Conclusions m TOR and PTEN may play an important role in esophageal squamous carcinoma, their joint detection may contribute to evaluate prognosis.

关 键 词：食管鳞状细胞癌 雷帕霉素靶蛋白 PTEN抑癌基因 

分 类 号：R735.1[医药卫生—肿瘤]