大蒜素对递增负荷训练大鼠血IFN-γ和IL-4的影响  

Effect of allicin on serum IFN-γ, IL-4 following incremental load training in rats

作　　者：付近梅 张夷 李少鹏[2] 张玮[3] 赵广高[4] 

机构地区：[1]江西省体育科学研究所,江西南昌330006 [2]江西师范大学体育学院,江西南昌330027 [3]江西中医药大学体育教学部,江西南昌330004 [4]南昌大学体育系,江西南昌330031

出　　处：《现代预防医学》2015年第4期682-684,700,共4页Modern Preventive Medicine

基　　金：江苏省自然科学基金项目(2011ZBZA204028)

摘　　要：目的研究大蒜素对过量运动大鼠Th1/Th2平衡的保护作用。方法清洁级8周龄雄性SD大鼠随机分为正常对照组(C组)、游泳训练组(T组)与大蒜素+游泳训练组(TA组),根据末次训练后取材的时间点不同,又各随机分为24 h组(C1、T1、TA1)与72 h组(C2、T2、TA2)2个小组。T组、TA组大鼠进行5周递增负荷游泳训练。TA组大鼠在训练的后3周每日注射大蒜素注射液,测定各组大鼠股动脉血血清IFN-γ、IL-4含量。结果 T组大鼠血清IFN-γ含量、IFN-γ/IL-4值均显著低于C组,T1组与T2组血清IFN-γ含量分别显著低于C1组与C2组;TA组大鼠血清IFN-γ含量、IFN-γ/IL-4值与T组相比无统计学差异。结论过量运动可使机体Th1/Th2平衡向Th2方向偏移,大蒜素对这种偏移无明显干预作用。Objective This work was to investigate the effect of allicin on Th1/Th2 balance after excessive exercise in rats. Methods SD rats aged 8 weeks were randomly divided into 3 groups： 1） Control （group C）, 2） Training （group T）, and 3） Training ＋ Allicin （group TA）. Each group was further randomly divided into two sub-groups according to the time of sampling： 1） 24 h post training （C1, T1, TA1） and 2） 72h post training （C2, T2, TA2）. Rats in group T and group TA performed incremental load swimming training for 5 weeks. The rats in group TA were injected with allicin every day in the last three weeks of training session. The concentrations of serum IFN-γ, IL-4 in the circulation were measured. Results Both the concentration of serum IFN- γ （P〈0.01） and the value of IFN- γ/IL-4 （P〈0.05） in group T were significantly lower than those in group C, and the concentrations of serum IFN- γ in group TI and T2 were significantly lower than that in group Cland C2 respectively. The levels of serum IFN- γ and IFN- γ/IL-4 in group TA showed no significant difference from that in group T. Conclusion Excessive exercise induced a shift to a Th2-type response, while allicin had no significant effect on such a shift.

关 键 词：大蒜素 TH1/TH2平衡 Γ-干扰素 白细胞介素-4 

分 类 号：R319[医药卫生—基础医学]