微生物降解没食子酸生产焦性没食子酸的研究进展  

Advance on Degrading Gallic Acid to Pyrogallic Acid Applying Microorganism

作　　者：李文君[1] 王成章[1,2] 

机构地区：[1]中国林业科学研究院林产化学工业研究所,生物质化学利用国家工程实验室,国家林业局林产化学工程重点开放性实验室,江苏省生物质能源与材料重点实验室,南京210042 [2]中国林业科学研究院林业新技术研究所,北京100091

出　　处：《中国实验方剂学杂志》2015年第3期226-231,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家高科技研究发展计划(863)项目(2014AA021802);国际合作项目(中俄项目)

摘　　要：焦性没食子酸是一种用途广泛的化工原料和试剂,多以化学法由没食子酸脱羧制备。文章针对该方法导致的严重环境污染和设备腐蚀等问题,从微生物转化的角度,重点综述降解没食子酸生产焦性没食子酸的微生物菌株及其相关工艺研究,如碳源、底物浓度、p H、发酵时间对焦性没食子酸得率的影响。同时也介绍了影响没食子酸脱羧酶(GAD)活性和产量的相关因素,如p H、温度、金属离子、添加剂等。然后,文章简要概括了利用微生物处理没食子单宁加工生产过程中的废水等问题。最后,文章通过展望了今后焦性没食子酸的生产制备工艺,作出了思考,为微生物转化法生产焦性没食子酸的工业化生产提供指导和参考。Pyrogallic acid, a widely used chemical raw material and reagent, was mostly prepared by the chemistry process of gallic acid decarboxylation. Since serious environment pollution and equipment corrosion with the above method, the article reviewed microbial strains and the related technology including mostly influence factors of yield, such as carbon sources, the concentration of substrate, pH and fermentation time from the perspective of microbial transformation. At the same time, related influence factors of the gallic acid decarboxylase （GAD） activity including pH, temperature, metal ions and additives were presented. Then, the article briefly introduced the treatment of wastewater made in the production process of gallotannin and other issues applying microorganism. Finally, some views and suggestions were put forward for the process for preparing pyrogallic acid with the new method in future, which would provide the guidance and reference for the industrial production of pyrogallic acid by microbial conversion.

关 键 词：焦性没食子酸 没食子酸 微生物转化法 没食子酸脱羧酶 没食子酸脱羧酶活性 

分 类 号：R284.1[医药卫生—中药学]