消癌顺气汤联合CAF化疗对147例乳腺癌患者T细胞亚群和血管内皮生长因子的影响及疗效分析  

The effect and effectiveness of eliminating cancer SHUNQI decoction combined with CAF chemotherapy on T cell subsets and Vascularendothelial growth factor of 147 cases with breast cancer

作　　者：李杰宝[1] 

机构地区：[1]湖北省武汉市第一医院甲乳外科,湖北武汉430033

出　　处：《海南医学院学报》2015年第3期381-383,共3页Journal of Hainan Medical University

基　　金：武汉巿科学技术计划项目(201262523846)~~

摘　　要：目的:探讨中药消癌顺气汤联联合CAF化疗方案对腺癌患者T细胞亚群和血管内皮生长因子的影响及疗效。方法:将147例肝郁气滞型乳腺癌患者随机分为3组,每组各为49例,对照组手术前未进行化疗及其他特殊治疗,化疗组患者手术前给予CAF化疗,观察组在化疗组基础上给予消癌顺气汤。比较3组治疗前后T细胞亚群CD4+、CD8+及CD4+/CD8+和者血管内皮生长因子(VEGF)的变化,比较三组术后生存时间和生活质量评分。结果:3个疗程后观察组VEGF水平明显低治疗前和于对照组及化疗组,差异具有统计学意义(P<0.05);CD4+及CD4+/CD8+水平明显高于化疗组,差异具有统计学意义(P<0.05);生存时间和中位缓解期明显长于对照组和化疗组,差异具有统计学意义(P<0.05);躯体功能、角色功能和情绪功能评分低于对照组和化疗组,差异具有统计学意义(P<0.05)。结论:消癌顺气汤能延长肝郁气滞型乳腺癌CAF化疗患者的生存期,改善术后生存质量,其机制可能与消癌顺气汤抑制VEGF作用,保护化疗前后的患者T细胞亚群有关。Objective： To investigate the effect and effectiveness of ShunQi decoction combined with CAF chemotherapy on T cell growth factor Vascularendothelial growth factor of 147 cases with breast cancer. Methods： 147 cases of patients with breast cancer patients were randomly divided into three groups, each group 49 cases. The control groups without chemotherapy and other special treatment before operation. The chemotherapy groups were given CAF chemotherapy before operation while the observation groups were given eliminating cancer SHUNQI decoction based on the chemotherapy groups. The level of T cell subsets of CD4^＋ , CD8^＋ and CD4^＋/CD8^＋ and vascular endothelial growth factor （VEGF） changes, the time and score of life quality for survival of three groupsbefore and after treatment were compared. Results： The level of VEGF in the observation groups after 3 months were significantly lower than that of before treatment and in the control group and the chemotherapy group （P〈0.05）. The levels of CD4^＋ and CD4^＋/CD8^＋ in the observation groups after 3 months were significantly higher than that in the chemotherapy groups （P〈0.05）. The survival time and median time to remission in the observation groups were longer than that in the control groups and the chemotherapy groups （P〈0.05）. The physical function, role function and emotional function scores were significantly lower than those in the control groups and the chemotherapy groups （P〈0.05）. Conclusions： Eliminating cancer SHUNQI decoction could significantly prolong the survival time and median time of breast cancer patients with CAF chemotherapy and improve the life quality after the operation. The mechanism may be related to eliminate cancer SHUNQI Decoction inhibiting VEGF function, protected T cell subsets before and after chemotherapy in patients.

关 键 词：乳腺癌 CAF化疗 消癌顺气汤 T细胞亚群 血管内皮生长因子 

分 类 号：R737.9[医药卫生—肿瘤]