右美托咪定对腹腔镜下胃癌手术七氟醚用量以及血清学指标的影响  

Effect of dexmedetomidine on sevoflurane dosage and serological indicators of laparoscopic gastric cancer operation

作　　者：赵正兰 方琴 王炎林[2] 

机构地区：[1]武汉市东西湖区人民医院麻醉科,湖北武汉430040 [2]武汉大学中南医院麻醉科,湖北武汉430071

出　　处：《海南医学院学报》2015年第3期390-392,396,共4页Journal of Hainan Medical University

基　　金：武汉市卫生局临床医学科研项目(WZ09D11)~~

摘　　要：目的:研究右美托咪定对腹腔镜下胃癌手术七氟醚用量以及血清学指标的影响。方法:将在本院接受腹腔镜下胃癌根治术的患者纳入研究,根据麻醉方式不同随机分为两组,观察组接受右美托咪定联合常规静吸复合麻醉,对照组接受常规静吸复合麻醉,比较两组的七氟醚用量、氧化应激指标以及红细胞葡萄糖代谢酶活性。结果:(1)七氟醚用量:输注右美托咪定10min后(T1)、建立气腹时(T2)、气腹后30min(T3)时,观察组七氟醚吸入浓度低于对照组,差异有统计学意义(P<0.05);(2)氧化应激损伤:观察组血浆丙二醛(MDA)含量低于对照组,还原型谷胱甘肽(GSH)、超氧化物歧化酶(SOD)含量高于对照组,差异有统计学意义(P<0.05);(3)红细胞葡萄糖代谢酶活性:观察组红细胞磷酸果糖激酶(PFK)含量高于对照组,葡萄糖-6-磷酸脱氢酶(G-6PD)、醛糖还原酶(AR)含量低于对照组,差异有统计学意义(P<0.05)。结论:右美托咪定辅助静吸复合麻醉有助于减少七氟醚用量、缓解氧化应激反应、改善红细胞葡萄糖代谢,是腹腔镜下胃癌手术的理想手术方法。Objective： To study the effect of dexmedetomidine on sevoflurane dosage and serological indicators of laparoscopic gastric cancer operation. Methods： patients received laparoscopic radical gastrectomy in our hospital from 2012.4-2014. 5 were enrolled randomly divided into two groups according to different anesthesia method. Observation group received dexme- detomidine combined with conventional intravenous inhalation anesthesia, control group received routine intravenous inhalation anesthesia. Then sevoflurane amount, oxidative stress index and erythroeyte glueosemetaholism enzyme activity were com- pared. Results： （1） sevoflurane dosage： 10 rain after dexmedetomidine infusion （T1）, pneumoperitoneum establishment（T2）, 30 rain after pneumoperitoneum （T3）, inhalation sevoflurane concentration of observation group were lower than those of control group; （2） oxidative stress injury： plasma MDA content of observation was lower than that of control group; GSH, SOD were lower than those of control group; （3） erythrocyte glucose metabolism enzyme activity： erythroeyte PFK content of observation group was higher than that of control group： G-6PD, AR content were lower than those of control group. Oonclusion： Dexmedetomidine assisted intravenous inhalation combined anesthesia are helpful to reduce sevoflurane amount, alleviate oxidative stress, improve erythrocyte glucose metabolism; it＇s an ideal operation method in laparoscopic gastric cancer operation.

关 键 词：右美托咪定 腹腔镜下胃癌手术 氧化应激 红细胞葡萄糖代谢 

分 类 号：R735.2[医药卫生—肿瘤]