三维适形放疗对鼻咽癌患者血清纤维化指标、肿瘤标志物、表皮生长因子及其受体的影响  

Observer the influence of three-dimensional conformal radiotherapy for the serum fibrosis markers,tumor markers,epidermal growth factor and its receptor of patients with nasopharyngeal carcinoma

作　　者：金鹏[1] 

机构地区：[1]湖北医药学院附属襄阳医院耳鼻喉科,湖北襄阳441000

出　　处：《海南医学院学报》2015年第3期427-429,432,共4页Journal of Hainan Medical University

基　　金：湖北省自然科学基金(hb2812234)~~

摘　　要：目的:观察三维适形放疗治疗鼻咽癌的疗效和安全性,分析其对患者血清纤维化指标、肿瘤标志物、表皮生长因子及其受体的影响。方法:将120例鼻咽癌患者随机分为两组,对照组和观察组各60例。对照组采用常规放疗,观察组则采用三维适形放疗。比较两组间近期疗效及大体肿瘤体积(GTVnx)和颈部转移淋巴结(GTVnd)差异;比较治疗前后两组间血清纤维化相关指标透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)和Ⅳ型胶原(ⅣC)水平以及肿瘤标志物巨噬细胞炎性蛋白-3α(MIP-3α)、糖类抗原125(CA125)水平以及表皮生长因子及其受体(EGF、EGFR)表达的差异。结果:观察组RR和CR明显高于对照组,差异具有统计学意义(P<0.05);接受放疗后第4、8周,观察组GTVnx和GTVnd均明显小于对照组,血清HA、LN、PCⅢ和ⅣC水平均明显低于对照组,血清MIP-3α、CA125、EGF和EGFR水平均低于对照组,差异均具有统计学意义(P<0.05)。结论:与常规化疗相比,三维适形放疗能有效降低对正常组织的损伤,提高肿瘤的局控率,在条件允许的前提下应尽可能的选择三维适形放疗治疗鼻咽癌。Objective： To observation the influence of three-dimensional conformal radiotherapy for the serum fibrosis markers, tumor markers, epidermal growth factor and its receptor of patients with nasopharyngeal carcinoma. Methods： 120 patients with nasopharyngeal carcinoma were randomly divided into control group and observation group, each group had 60 cases, all the patients were treated with conventional radiotherapy, patients in observation group were treated by three-dimensional conformal radiotherapy. Then the recent effect and the gross tumor volume （GTVnx） and cervical lymph node metastasis （GTVnd） of two groups were compared. And the serum levels of fibrosis markers such as hyaluronic acid （HA）, laminin （LN）, Ⅲ procollagen （PCⅢ） and type Ⅳ collagen （IVC）, and tumor markers such as macrophage inflammatory protein -3α （MIP-3α）, carbohydrate antigen 125 （CA125） level and epidermal growth factor and its receptors （EGF, EGFR） of two groups before and after treatment were also compared. Results： The RR and CR of observation group were significantly higher than those in the control group, P〈0.05. After 4, 8 weeks of radiotherapy, the GTVnx and GTVnd of observation group were significantly lower than those of control group, and the serum levels of HA, LN, PC III and IVC were obviously lower than those of control group, and the serum levels of MIP-3 alpha, CA125, EGF and EGFR were also significantly lower than those in the control group, all P 〈 0.05. Conclusion：Compared with conventional chemotherapy, three-dimensional conformal radiotherapy can relieve the injury to normal tissues, improve the tumor local control rate, so should as far as possible choice the three dimensional conformal radiotherapy for nasopharyngeal carcinoma as much as reasonably possible.

关 键 词：鼻咽癌 三维适形放疗 纤维化 肿瘤标志物 表皮生长因子 

分 类 号：R739.6[医药卫生—肿瘤]