脑卒中与线粒体动态变化的研究进展  

Progress in the regulation of mitochondrial dynamics in cerebral ischemia

作　　者：江涛 李立亚 王强[1] 

机构地区：[1]第四军医大学第一附属医院麻醉科,西安710032

出　　处：《国际麻醉学与复苏杂志》2015年第2期182-185,I0001,共5页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金（81072888）

摘　　要：背景线粒体是细胞中氧化磷酸化和合成ATP的主要场所，对于维持细胞内稳态起到非常重要的作用。目的以线粒体动态变化为核心，通过总结其在缺血性脑卒中中的作用，为相关领域研究提供参考。内容线粒体是一个高度动态变化的细胞器，不断进行着生物发生、自噬、融合与分裂等变化。大量研究证明线粒体的动态变化在脑缺血的多种损伤与修复阶段起到重要作用。趋向增强线粒体的生物发生，调节线粒体自噬和融合分裂，通过调节线粒体的功能，减轻脑缺血损伤，提供有效的神经保护作用策略。Background Mitochondria is a major intracellular compartment for ATP production via oxidative phosphorylation. The function of mitochondria is pivotal for the maintenance of cell homeostasis. Objective Focusing on the dynamic changes of mitochondrial function, we summarized its function in ischemic cerebral injury to provide new insights into related academic fields. Content The mitochondria is constantly undergoing dynamic, including mitochondrial biogenesis, mitophagy, fission and fusion. Numerous studies have demonstrated that mitoehondrial dynamics play an important role in various kinds of injuries and repair processes in cerebral ischemia. Trend Bolstering mitochondrial biogenesis and regulating mitophagy, fission and fusion could reduce ischemic brain injury via regulating mitochondria function, thus provide an effective neuroprotective strategy

关 键 词：脑卒中 线粒体动态变化 

分 类 号：R743.3[医药卫生—神经病学与精神病学]