甲钴胺对H型高血压患者血浆炎性因子及颈动脉斑块的影响  

Impacts of mecobalamin on plasma inflammatory factors and carotid artery plaques in patients with H type hypertension

作　　者：杨峰[1] 郭民旺[1] 周汝娟[1] 何龙锦[1] 汪小荣[1] 

机构地区：[1]江苏省泰兴市人民医院神经内科,225400

出　　处：《中国综合临床》2015年第1期30-32,共3页Clinical Medicine of China

摘　　要：目的观察甲钴铵对H型高血压血浆炎性因子[血浆超敏C反应蛋白（hs—CRP）]及颈动脉斑块的影响。方法选取在我院住院的48例H型高血压的急性脑梗死患者，随机分为干预组24例和常规治疗组24例两组，均给予抑制血小板聚集、稳定和缩小斑块等脑梗死的常规治疗，干预组在常规治疗基础之上予甲钴胺500μg口服，一日3次，连用6个月。分别在住院第2天、4周后、8周后、3个月、6个月，检On,02组患者同型半胱氨酸（Hey）、hs．CRP水平及B超行颈动脉斑块。结果治疗4周后、8周后、3个月、6个月后，干预组Hey水平与对照组比较差异均有统计学意义（t值分别为4．049、3．896、6．052、6．159；P均〈0．05）；治疗4周后、8周后、3个月、6个月后干预组hs—CRP水平与对照组比较差异均有统计学意义（t值分别为37．249、28．376、26．454、20．522；P均〈0．01）；治疗3个月、6个月后颈动脉斑块显著缩小，与对照组比较差异均有统计学意义（t值分别为2．309、2．434，P均〈0．05）。结论予以甲钻胺可降低血浆Hey水平，达到降低血浆炎性因子水平及缩小颈动脉斑块的作用。Objective To investigate the impacts of mecobalamin on plasma inflammatory factors （plasma high-sensitivity C-reactive protein （Hs-CRP） and carotid artery plaques in patients with H type hypertension. Methods Forty-eight acute ischemic stroke patients who were diagnosed with H type hypertension in the People＇s Hospital of Taixing were collected, and they were randomly divided them into treatment group and control group ,and 24 cases of each group. Patients in both groups were given conventional therapies, including treatment of anti platelet aggregation, plaque stability and reduced plaque treatment. While patients in the treatment group were given additional oral drug of mecobalamin ,500 [xg each time, three times a day ,6 months in all. Each case was evaluated at the second day of hospitalization, four weeks later, eight weeks later, three months and sixth months later. The examination items involved included level of plasma homoeysteine （Hcy）, level of hs- CRP and conditions of carotid artery plaques under ultrasonography. Results Aafter four weeks, eight weeks, three months and sixth months therapy, there were significant differences between treatment group and control group in terms of Hey （ t = 4. 049,3. 896,6. 052,6. 159 ; P 〈 0. 05 ） and the level of hs-CRP （ t = 37. 249, 28. 376,26. 454,0. 522P 〈 0. O1 ）. Afrter three months and sixth months therapy, compared to the control group, the carotid artery plaques were obviously reduced, and the differences were statistically significant （ t = 2. 309, 2. 434 ; P 〈 0. 05 ）. Conclusion Mecobalamin can reduce the level of plasma homocysteine, then lead to reductions of levels of plasma inflammatory factors and volume of carotid artery plaques.

关 键 词：甲钴胺 H型高血压 血浆炎性因子 颈动脉斑块 

分 类 号：R743.33[医药卫生—神经病学与精神病学]