鸟氨酸脱羧酶与女性常见恶性肿瘤  

Ornithine decarboxylase and common female malignant tumors

作　　者：占景琼[1] 佐满珍[1] 王艳林[1] 

机构地区：[1]三峡大学医学院三峡大学分子生物学研究所,湖北宜昌443002

出　　处：《海南医学》2015年第2期211-213,共3页Hainan Medical Journal

基　　金：国家自然科学基金(编号:81372265)

摘　　要：鸟氨酸脱羧酶(Ornithine decarboxylase,ODC)是调控细胞内多胺生物合成的限速酶,参与胚胎发育、细胞周期、细胞增殖分化等重要的生理过程,同时也是肿瘤细胞的快速增殖所必须,是目前研究较多的抗肿瘤治疗的潜在分子靶点之一。本文简要综述ODC与女性常见恶性肿瘤关系的研究进展。Ornithine decarboxylase（ODC） is the first rate-limiting enzyme in regulating intracellular polyamine biosynthesis and is involved in many important physiological functions including embryonic development,cell cycle,cell proliferation and differentiation.In the same time,ODC is also needed by tumor cells for their rapid proliferation.Currently,it has been regarded as a potential molecular target for anti-tumor therapy.This article briefly reviews the research progress in the relationship between ODC and several common female malignant tumors.

关 键 词：鸟氨酸脱羧酶 多胺代谢 女性恶性肿瘤 

分 类 号：R737.3[医药卫生—肿瘤]