上皮性卵巢癌中HOST2 lncRNA的表达及临床意义  

Expression of HOST2 lnc RNA in Ovarian Epithelial Carcinoma and Its Clinical Significance

作　　者：刘静[1] 彭萍[1] 汪先桃[1] 

机构地区：[1]成都市龙泉驿区第一人民医院,四川成都610100

出　　处：《中国医学创新》2015年第3期34-36,共3页Medical Innovation of China

基　　金：成都市卫生局科学研究基金项目资助(201111)

摘　　要：目的:检测HOST2 lnc RNA在上皮性卵巢组织的表达水平,并分析其临床意义。方法:利用实时荧光定量PCR方法检测HOST2 lnc RNA在上皮性卵巢癌、上皮性交界性瘤和上皮性正常卵巢组织的表达水平,分析HOST2 lnc RNA在不同上皮性卵巢组织表达差异的临床意义。结果:HOST2 lnc RNA在上皮性卵巢癌组织和上皮性交界性瘤表达量明显高于上皮性正常卵巢组织的表达,差异均有统计学意义(P<0.01)。HOST2 lnc RNA在上皮性卵巢癌组织表达量与上皮性交界性瘤表达量比较无明显差异(P>0.05)。HOST2 lnc RNA在不同临床分期的上皮性卵巢癌中表达量无明显差异(P>0.05)。结论:在上皮性卵巢癌和交界性卵巢瘤中HOST2 lnc RNA均有表达,可作为上皮性卵巢癌早期诊断的一个分子诊断标志物。Objective：To detect the expression of HOST2 lnc RNA in epithelial ovarian carcinoma, and analyze its clinical significance.Method：The HOST2 expression of epithelial ovarian cancer, epithelial borderline tumor and epithelial ovarian normal tissues were detected by the PCR method. Clinical significance differences in the expression of HOST2 lnc RNA in different ovarian tissue was analyzed.Result：Expression of epithelial ovarian cancer tissue and epithelial borderline tumor was obviously higher than expression of epithelial normal ovarian tissues,there was significant statistical difference（P〉0.01）. HOST2 lnc RNA＇s expression of epithelial ovarian cancer tissue was no significant difference with the expression of epithelial borderline tumor tissue（P〉0.05）.HOST2 lnc RNA＇s expression of different clinical stages of epithelial ovarian tumor was no significant difference（P〉0.05）. Conclusion：HOST2 lnc RNA expression in ovarian cancer and epithelial borderline tumor, maybe a marker for early diagnosis of ovarian cancer.

关 键 词：HOST2 lncRNA 实时荧光定量PCR 卵巢癌 

分 类 号：R737.31[医药卫生—肿瘤]