缺血性脑中风中与内质网应激相关炎症反应研究进展  

Research progress of inflammation reaction related to endoplasmic reticulum stress in ischemic endoplasmic reticulum stress

作　　者：黄志英[1,2] 张晓旭[1,3] 孙文利[1,3] 陈畅[1] 李德凤[1] 方婧[1] 付梅红[1] 刘庆山[4] 颜天华[2] 李韶菁[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]中国药科大学药学院,江苏南京210009 [3]河北大学药学院,河北保定071002 [4]中央民族大学中国少数民族传统医学研究院,北京100081

出　　处：《中国药理学通报》2015年第1期23-26,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81274133,81303261);国家科技重大专项(重大新药创制)资助项目(No2012ZX09103201-055)

摘　　要：内质网是机体微环境的重要组成结构和功能单位,内质网内稳态失衡导致的内质网应激成为近年来的一个研究热点。该文主要针对内质网应激在缺血性脑中风中的作用及相关信号通路的研究进展进行综述,特别对内质网应激触发脑中风炎症反应的机制进行了系统的整理和总结,以期为缺血性中风的防治提供新的研究思路。Endoplasmic reticulum plays a key role in both basic structure formation and function performance of microenviron-ment. Endoplasmic reticulum homeostasis unbalance caused by endoplasmic reticulum stress has become a hot research topic in recent years. This paper focuses on the role of endoplasmic retic-ulum stress in ischemic stroke. Research progress of related sig-naling pathways were reviewed, especially mechanisms through＆amp;nbsp;which endoplasmic reticulum stress trigger the inflammatory reac-tion, so as to provide a new research method for prevention of is-chemic stroke.

关 键 词：缺血性脑中风 神经元损伤 微环境 内质网应激 炎症 相关信号通路 

分 类 号：R-05[医药卫生] R329.24