宁夏城市社区中老年人非酒精性脂肪性肝病现况及其影响因素分析  

Analysis of the current status of the prevalence and its relative factors of non-alcoholic fatty liver disease in urban community in Ningxia province

作　　者：王志忠[1] 余白露 马万瑞[2] 丁莉[1] 刘兰[1] 李涛[1] 张金玲[2] 

机构地区：[1]宁夏医科大学公共卫生学院流行病与卫生统计学系,银川750004 [2]宁夏医科大学总医院综合科

出　　处：《中华老年医学杂志》2015年第1期82-85,共4页Chinese Journal of Geriatrics

基　　金：宁夏自然科学基金项目（NZ1082）

摘　　要：目的 了解社区中老年人非酒精性脂肪性肝病的现况,比较回、汉族人群非酒精性脂肪性肝病患病率的差异及其可能的影响因素. 方法 采用典型抽样法选取宁夏银川市和吴忠市老年人口比例较高的5个城市社区,对社区内55岁及以上符合标准的1046例居民进行问卷调查和临床检查,并采集空腹血样本对总胆同醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇等生化指标进行检测. 结果 共有1043例完成了全部检查,平均年龄（66.4±6.7）岁;汉族696例（66.7％）,回族347例（33.3％）.符合非酒精性脂肪性肝病诊断标准者286例,患病率为27.4％,男性患病率为23.4％（94例）,女性患病率为29.9％（192例）,男女性患病率差异有统计学意义（Х^2=5.18,P=0.023）;回族患病率28.2％（98例）,汉族患病率27.0％（188例）,患病率差异无统计学意义（Х^2=0.17,P=0.675）.非条件Logistic回归分析结果显示,年龄（OR=0.96,95％ CI：0.94-0.99）、体质指数（OR=1.31,95％CI：1.24-1.38）、三酰甘油（OR=1.71,95％CI：1.47-1.98）、中心性肥胖（OR=5.20,95％CI：2.21-12.23）与中老年人患脂肪肝有相关性. 结论 回、汉族中老年人非酒精性脂肪性肝病患病率差异无统计学意义,超重者、中心性肥胖、血清三酰甘油水平高的中老年人患病风险增加.Objective To investigate the current status of prevalence and its relative factors of non-alcoholic fatty liver disease （NAFLD） in the elderly in urban community in Ningxia province and to compare the differences in prevalence of NAFLD between Han and Hui ethnicities.Methods 1046 residents aged 55 years and over from five communities were selected.Questionnaire survey and clinical examination were conducted in all subjects.Fasting vein blood samples were collected.The serum total cholesterol,triglyceride,high density lipoprotein cholesterol,low density lipoprotein cholesterol were detected.Results There were 1043 subjects with average age of （66.41 6.65） years finishing the whole examination,including 696 （66.7%） Han and 347 （33.3%） Hui people.The total prevalence of NAFLD was 27.0% （286/1043）,and there was a significant difference in the prevalence [23.4% （94 cases） vs.29.9% （192 cases）,Х^2 =5.18,P=0.023]between male and female,but no difference between Han and Hui ethnicities [28.2% （98 cases） vs.27.0% （188 cases） Х^2 =0.17,P=0.675].Logistic regression showed that age（OR=0.96,95% CI：0.94-0.99）,BMI（OR=1.31,95% CI：1.24-1.38）,TG（OR=1.71,95% CI：1.47-1.98）,central obesity （CO）（OR=5.20,95%CI：2.21-12.23） were the factors correlating with NAFLD.Conclusions The prevalence of NAFLD in Hui elderly people was is similar to that in Han elderly people.The elderly people with overweight,central obesity and high serum level of triglyceride and high level TG have higher risk for NAFLD.

关 键 词：脂肪肝 性腺甾类激素 危险因素 

分 类 号：R575.5[医药卫生—消化系统]