益生菌联合乳果糖治疗肝性脑病的疗效观察  

Efficacy of Probiotics combined lactulose in treatment of hepatic encephalopathy: an observation

作　　者：王超[1,2] 林志辉[1,2] 陈贻胜[1,2] 

机构地区：[1]福建医科大学省立临床学院 [2]福建省立医院消化内科,福建福州350001

出　　处：《中国微生态学杂志》2014年第12期1425-1427,共3页Chinese Journal of Microecology

摘　　要：目的观察益生菌联合乳果糖治疗肝性脑病的疗效。方法对我院2010年1月至2013年12月期间收治的106例肝性脑病患者治疗效果进行回顾性分析。随机分为对照组、乳果糖组(A组)、益生菌联合乳果糖组(B组)。结果三组患者血清谷丙转氨酶、总胆红素、血氨水平、数字连接实验(NCT)均有改善,其中A、B组各指标较治疗前有明显改善(P<0.05),且明显优于对照组(P<0.05);而B组效果优于A组,差异有统计学意义(P<0.05)。结论在常规综合治疗基础上采用益生菌联合乳果糖能够显著促进肝功能的恢复并降低血氨水平,减轻肝昏迷症状,达到治疗肝性脑病目的;疗效明显优于单纯常规综合治疗及单独加用乳果糖,且无明显不良反应,在临床上值得加以推广应用。Objective To observe the effect of Probiotics combined lactulose for treatment of hepatic encephalopa- thy. Methods A retrospective review was performed on the outcome of 106 patients with hepatic encephalopathy in our hospital from January 2010 to December 2013. The cases were randomly divided into control group, lactulose group （group A）, and Probiotics combined lactulose group （group B）. Results The alanine aminotransferase （ ALT）, total bilirubin （ TBiL）, blood ammonia （ NH3 ）, the number connection test （NCT） result were improved in the three groups after treatment ; the parameters improved significantly in the group A and B （ P 〈 0. 0） than before treatment, and were superior to those of control group （ P 〈 0. 05 ） , with the efficacy rate of group B significantly higher than that of group A （ P 〈 0. 05 ）. Conclusion On the basis of routine comprehensive treatment, probiotics combined lactulose can significantly promote the recovery of liver function, lower the blood ammonia level, and alleviate symptoms of hepatic coma, thus effectively treat hepatic eneephalopathy. The efficacy is superior to that of conventional treatment alone or combined with lactulose alone, with no significant side effects.

关 键 词：肝性脑病 益生菌 乳果糖 

分 类 号：R747.9[医药卫生—神经病学与精神病学]