芽殖酵母ASH1 mRNA的定位机制  

ASH1 mRNA localization in budding yeast

作　　者：张前军[1] 李德玲[1] 顾巍[1] 

机构地区：[1]汕头大学医学院病理生理学教研室,汕头515041

出　　处：《生命的化学》2014年第6期732-736,共5页Chemistry of Life

基　　金：国家自然科学基金资助项目(31171209)

摘　　要：mRNA定位是一种基因转录后水平的重要调控机制,对细胞的生理活动和分化发育都有着极其重要的作用。在芽殖酵母有丝分裂中,ASH1 mRNA在子细胞芽尖因不对称定位表达抑制了子细胞交配类型的转换。本综述介绍了芽殖酵母ASH1 mRNA定位的分子机制。mRNA localization is a mechanism for post-transcriptional regulation of gene expression and plays an important role in cellular activities including differentiation and development. In budding yeast, the localization of ASH1 mRNA results in asymmetric expression of its corresponding protein, thus inhibiting the mating type switch in the daughter cells. This review introduces the mechanism of ASH1 mRNA localization in budding yeast.

关 键 词：ASH1 MRNA 酵母 转录后调控 

分 类 号：Q93[生物学—微生物学]