不同剂量阿托伐他汀对短暂性脑缺血发作转归的影响  

Effects of atorvastatin on patients with transient ischemic attack

作　　者：孙永安[1] 何效兵[1] 陶爱华[1] 

机构地区：[1]徐州医学院附属连云港医院神经内科,连云港222002

出　　处：《中国实用神经疾病杂志》2014年第22期3-5,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的观察阿托伐他汀对短暂性脑缺血发作(TIA)患者转归的影响。方法 130例TIA患者随机分为高剂量(40mg/d)阿托伐他汀治疗组(H组)和低剂量(10mg/d)阿托伐他汀治疗组(L组)各65例,2组患者均给予相同的基础治疗。观察2组患者住院及随诊1a期间TIA复发及形成梗死、新发冠脉事件、脑出血及死亡情况,并比较2组1a点LDL水平。结果住院期间和随访期间,H组TIA复发率、梗死及新发冠脉事件发生率及LDL水平明显低于L组。结论高剂量(40mg/d)阿托伐他汀能显著改善短暂性脑缺血患者的发作,值得临床推广。Objective To investigate the effect of atorvastatin on patients with transient ischemic attack （TIA）. Methods One hundred and thirty patients with TIA were randomly divided into the high dose of atorvastatin （40 mg/d ,H group） and low dose of atorvastatin （40 mg/d ,L group）. The recurrence and forming cerebral infarction ,new coronary events ,cerebral hemorrhage and death ,and LDL level of two groups were compared.Results The TIA recurrence rate ,cerebral infarction and less new coronary events and LDL level of H group were lower than these of L group. Conclusion The high dose of atorvasta-tin （40 mg/d） can significantly improve the attack of patients with transient cerebral ischemia ,which is worthy of application.

关 键 词：阿托伐他汀 短暂性脑缺血发作 

分 类 号：R743.31[医药卫生—神经病学与精神病学]