初发精神分裂症患者神经认知功能早期受损状况调查  

The survey of impaired neurocognitive function in patients with first-episode schizophrenia

作　　者：刘磊峰[1] 贺定翠[1] 邓小鹏[1] 凃哲明 刘波[1] 

机构地区：[1]湖北荆州市精神卫生中心,荆州434000

出　　处：《中国实用神经疾病杂志》2014年第22期13-16,共4页Chinese Journal of Practical Nervous Diseases

摘　　要：目的通过分析初发精神分裂症患者与健康人群认知功能的差异,探讨初发精神分裂症患者早期神经认知功能缺陷的程度与特点。方法选取住院的初发精神分裂症患者120例为患者组,健康人群120例为对照组,采用阳性与阴性症状量表、成套神经认知功能测验全面评定患者的精神症状与认知功能。结果 (1)阳性症状、阴性症状、一般精神病理以及PANSS总分无性别差异(P>0.05)。(2)在11项神经认知功能测验中,患者组与对照组之间差异显著(P<0.05),患者组学习和记忆、精细动作、信息处理速度以及执行功能的成绩显著低于对照组(P<0.001)。(3)男患者的颜色连线2测验(P<0.05)、Stroop色词测验(单词总数P<0.05,颜色总数P<0.05,色/词总数P<0.01)、WMS-Ⅲ空间广度总分(P<0.01)的成绩显著低于女患者。结论初发精神分裂症患者的认知功能全面损害,且男性患者执行功能与视觉空间记忆的缺陷更严重。Objective To investigate the neurocognitive function of patients with first-episode schizophrenia by comparing the difference between schizophrenia group and health group.Methods One hundred and twenty patients with first-episode schizophrenia were considered as the patient group ,and 120 normal people were considered as the control group. The psychiat-ric symptoms and cognitive function of two groups were evaluated by a positive and negative syndrome scale and a set of neuro-psychological test battery. Results The neuropsychological function ,learning and memory ,fine movement ,information pro-cessing speed and executive function of patients group were lower than these of control group ;the color trail making test 2 , stroop color word test and WMS-Ⅲ spatial span of male patients were lower than female patients. Conclusion The neuropsy-chological function ,executive function and visual space memory of patients with first-episode schizophrenia have severe impair-ment ,especially in the male patients.

关 键 词：初发精神分裂症 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]