平阳霉素碘化油混合乳剂(PLE)动脉栓塞在肝血管瘤介入治疗中的临床疗效评价  

Clinical efficacy of arterial embolization in treatment of hepatic hemangioma by Pingyang mycin lipiodol emulsion

作　　者：易军 

机构地区：[1]湖北省应城市人民医院放射科,湖北应城432400

出　　处：《海南医学院学报》2014年第12期1714-1717,共4页Journal of Hainan Medical University

基　　金：湖北省自然科学基金(2012FFB02318)~~

摘　　要：目的:探讨平阳霉素碘化油混合乳剂(PLE)动脉栓塞在肝血管瘤介入治疗中的临床疗效。方法:将80例肝血管瘤患者随机地分为对照组(n=38)与观察组(n=42),分别采用碘化油乳剂与PLE栓塞治疗。比较两组动脉造影征象、临床疗效、治疗前后肝血管瘤直径及血清总胆汁酸(TBA)水平变化、下床时间、住院时间、治疗满意度及并发症发生情况。结果:(1)动脉早期可见周边部位出现体积较大的血管湖影,呈"枝上挂果征"变化;静脉期或静脉后期较动脉早期出现更多血管湖影,且均不排空,呈"早出晚归征"变化;(2)对照组临床总有效率为明显低于观察组,差异具有统计学意义(P<0.05);(3)两组治疗后肝血管瘤直径及血清TBA水平均明显减小,且观察组治疗后血管瘤直径及血清TBA水平均明显小于对照组治疗后,差异具有统计学意义(P<0.05);(4)观察组下床时间、住院时间均明显小于对照组,观察组治疗满意度评分明显高于对照组,差异具有统计学意义(P<0.05);(5)两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:PLE动脉栓塞治疗肝血管瘤的临床疗效明显,安全性高,应加以推广及应用。Objective： To investigate the clinical efficacy of arterial embolization in treatment of hepatic hemangioma by Pingyang mycin lipiodol emulsion （PLE） . Methods： A total of 80 cases of hepatic hemangioma were randomly divided into control group （n= 38） and observation group （n=42） according to the treatment. And they were respectively given with lipi- odol emulsion embolization and PLE. The clinical efficacy, the angiographic signs, cavernous hemangioma of liver and serum total bile add （TBA in diameter） levels before and after treatment, getting out of bed time, hospitalization time, treatment satisfaction and complications were compared. Results： Larger vascular lake shadow appeared in artery early visible surround- ing parts, demonstrated as ＂branches hanging fruit syndrome＂ change; there were more shadow without evacuation at advanced stage, demonstrated as ＂spare＂ sign change. The clinical total effective rate of control group was 76.32%, significantly lower than the observation group （92.86% （P〈 0.05）. In two groups after treatment of liver hemangioma diameter and serum TBA levels were significantly decreased, and in the observation group after treatment of hemangioma diameter and serum TBA levels were significantly lower than the control group after treatment （P〈 0.05）. In the observation group under the bed time,hospitalization time was significantly shorter than that of the control group （P〈 0.05）, in observation group treatment satis- faction score was significantly higher than that in control group （P〈0.05）. There was no significant difference in incidence of adverse reaction of two groups （P〈 0.05）.Conclusion： The curative effect of PLE artery embolization in the treatment of liver hemangioma is significant and highly safe. It is worthy promoting and application.

关 键 词：肝血管瘤 平阳霉素碘化油混合乳剂 动脉造影 动脉栓塞 

分 类 号：R735.7[医药卫生—肿瘤]