同步放化疗治疗中晚期宫颈癌的疗效及预后影响因素  

Effects of concurrent chemotherapy plus radiotherapy in treatment of advanced cervical cancer and relevant prognostic factors

作　　者：刘俊[1] 张开军[1] 翟志刚[1] 游涛[1] 戴东方[1] 

机构地区：[1]江苏大学附属医院放疗科,江苏镇江212001

出　　处：《海南医学院学报》2014年第12期1733-1735,1738,共4页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金(11321353)~~

摘　　要：目的：观察同步放化疗治疗中晚期宫颈癌的疗效,并探讨其预后影响因素。方法：回顾性分析2006年1月~2010年8月期间100例中晚期宫颈癌患者的临床资料,根据所采取治疗方案不同,分为同步放化疗组54例,放射治疗（放疗）组46例,比较其近期疗效、不良反应和3年生存率（OS）;根据3年后是否存活,将同步放化疗组分为存活组38例和死亡组16例,探讨预后影响因素。结果：同步放化疗组与放疗组总有效率比较,差异具有统计学意义（P〈0.05）;同步放化疗组骨髓抑制发生率明显高于放疗组,差异具有统计学意义（P〈0.05）;同步放化疗组3年OS明显高于放疗组,差异具有统计学意义（P〈0.05）;单因素分析表明,存活组与死亡组之间病理分型、肿瘤直径、淋巴结转移情况以及是否贫血比较,差异具有统计学意义（P〈0.05或P〈0.01）;Logistic回归分析表明,病理分型、是否有淋巴结转移以及是否贫血是3年OS的独立影响因素（P〈0.05或P〈0.01）。结论：同步放化疗可有效提高中晚期宫颈癌的近期疗效和远期生存率,病理分型、淋巴结转移情况以及是否贫血是预后的影响因素。Objective： To observe the clinical effects of concurrent chemotherapy plus radiotherapy in treatment of ad- vanced cervical cancer and to discuss the protential prognostic factors. Methods： Clinical data of 100 patients with advanced cervical cancer between Jan 2006 and Aug 2010 were retrospectively analyzed. Patients were divided into concurrent therapy group （n=54） and radiotherapy group （n=46）, respectively. Short-term effects, adverse reaction and three years overall survival of patients from different groups were analyzed. Data of patients in concurrent therapy group were selected for prognostic factors analysis. Results： Overall response rate was 88. 89% in concurrent therapy and 69.57% in radiotherapy group （P〈0. 05）. In- cidence of bone marrow suppression （P〈0.05） and three year overall survival rate in concurrent therapy group were signifi- cantly higher （P〈0.05））. Univariate analysis showed significant difference in pathological type, size of tumor, lymphatic me- tastasis and occurrence of anemia between survival and dead patients in concurrent therapy group （P〈0.05, P〈0.01）. Logis- tic regression analysis indicated the pathological type, lymphatic metastasis and anemia were independent risk factors for prog-nosis. Conclusions： Concurrent chemotherapy plus radiotherapy has potential to improve the short and long term outcomes. Pathological type, lymphatic metastasis and anemia are potential independent risk factors for prognosis of cervical cancer .

关 键 词：宫颈癌 同步放化疗 骨髓抑制 病理分型 淋巴结转移 预后 

分 类 号：R737.3[医药卫生—肿瘤]