启东地区男性体检人群脂肪肝患病率及相关因素的横断面分析  

Fatty liver prevalence and related serological risk factors in male population: a cross-sectional analysis in Qidong city

作　　者：袁佳平[1] 樊健[1] 樊春笋[2] 姚红玉[2] 陈陶阳[2] 张亚玮[2] 

机构地区：[1]启东市人民医院体检中心,江苏省226200 [2]启东市人民医院病因室,江苏省226200

出　　处：《中华临床医师杂志（电子版）》2014年第21期90-93,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的了解启东地区男性脂肪肝患病率及与血清生化指标之间的关联。方法采用横断面分析方法,从2013年1~12月在启东市人民医院体检中心参加体检的人员中整群随机抽取7个单位的男性体检者,根据超声结果诊断脂肪肝并计算患病率,采用t检验、Wilcoxon秩和检验及Logistic回归分析血清生化指标与脂肪肝患病之间的关联。结果纳入本研究的男性体检者共3863名,平均年龄（54.32±14.47）岁,超声检出脂肪肝1 421例,患病率为36.78%。t检验或Wilcoxon秩和检验结果提示血谷丙转氨酶、谷氨酰转肽酶、尿酸、空腹血糖、总胆固醇、甘油三酯与脂肪肝患病间存在关联（P均〈0.05）。Logistic回归结果证实血谷丙转氨酶、谷氨酰转肽酶、尿酸、空腹血糖、甘油三酯高于临床正常值为脂肪肝患病的独立危险因素,调整后的比值比（95%置信区间）分别为3.06（2.46~3.79）、2.08（1.77~2.45）、1.60（1.37~1.86）、2.68（2.14~3.37）、3.00（2.53~3.54）。结论启东地区男性体检者中血肝功能、糖、脂及尿酸指标异常者为患脂肪肝高危人群,对此类人员可采取积极干预措施。Objective To investigate prevalence of fatty liver disease and its association with serological factors in male population of Qidong city. Methods Using a cross-sectional design, male subjects fi＇om seven institutions who had undergone annual health check-up from January 2013 to December 2013 in Qidong people hospital were recruited by cluster sampling method. Fatty liver disease as an independent variable was confirmed by abdominal ultrasound. Data of serum biochemical factors were cleaned, sorted and treated as explanatory variables. T test, Wilcoxon sum rank test and logistic regression model were introduced to evaluate the association, between serum biochemical parameters and fatty liver disease. Results Among the total 3 863 male subjects [average age： （54.32±14.47）years], 1 421 had fatty liver disease, which generated a prevalence of 36.78%. Results after T test suggested that alanine aminotransferase （ALT）, gamma glutamyltranspeptidase （GGT）, fasting glucose （Glu）, uric acid （UA）, total cholesterol （TC）, and triglyceride （TG） were correlated with fatty liver disease （P〈0,05）. Further logistic regression analysis convinced that ALT, GGT, Glu, UA, and TG were independent risk factors of fatty liver disease.Adjusted odds ratio and 95% confidence interval were 3.06（2.46-3.79）, 2.08（1.77-2.45）, 1.60（1.37-1.86）, 2.68（2.14-3.37）, 3.00（2.53-3.54） separately. Conclusion Male persons who have abnormal serum results are prone to suffer from fatty liver disease; therefore, more active preventive strategy should be introduced in such high-risk population.

关 键 词：脂肪肝 横断面研究 LOGISTIC模型 

分 类 号：R575.5[医药卫生—消化系统]