体部γ刀立体定向放疗联合高强聚焦超声治疗中晚期胰腺癌12例临床分析  

Body gamma knife combined with high intensity focused ultrasound in the treatment of advanced pancreatic cancer in 12 cases

作　　者：杜海峰 魏长宏 王作志 赵永生 卞晓山 傅振强 

机构地区：[1]武警山东省总队医院肿瘤科放疗中心,济南250014

出　　处：《中华实用诊断与治疗杂志》2015年第1期67-69,共3页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的观察体部γ刀立体定向放疗（stereotactic body radiation therapy,SBRT）联合高强聚焦超声（high intensity focused ultrasound,HIFU）治疗中晚期胰腺癌的近期疗效及安全性。方法中晚期胰腺癌患者12例,给予SBRT联合HIFU治疗。SBRT取等剂量线为50%～60%,肿瘤单次周边剂量3.0～4.0Gy,总剂量35～48Gy,8～12次,1次/d,5次/周;SBRT期间,SBRT后2～4h行HIFU治疗,1次/周,靶区温度控制在42℃以上,共3～5次。观察近期临床疗效及不良反应发生情况。结果治疗结束后2～3个月,肿瘤完全缓解1例,部分缓解8例,无变化1例,恶化2例,近期总有效率75.0%;治疗后11例伴疼痛者疼痛缓解9例,8例合并黄疸者黄疸消退6例;治疗期间出现恶心、呕吐10例,白细胞下降7例,血小板降低5例,均经对症治疗恢复正常。结论 SBRT联合HIFU治疗中晚期胰腺癌疗效满意,不良反应可耐受。Objective To observe the short-term effect and safety of stereotactic body radiation therapy（SBRT）combined with high intensity focused ultrasound（HIFU）in the treatment of advanced pancreatic cancer.Methods Twelve patients with advanced pancreatic cancer received SBRT plus HIFU.The isodose curve of SBRT was 50% to 60%,tumor single peripheral dose was 3 to 4.0Gy,and the total dose was 35 to 48Gy,once a day for 8 to 12 times,five times per week.In 2 to 4hours after SBRT,the patients received HIFU,once a week,totally for 3 to 5 times at the target zone temperature of over 42 ℃.The short-term effect and adverse reaction were observed.Results After 2-to 3-month treatment,complete remission occurred in 1 patient,partial remission in 8,no change in 1,and deterioration in 2,with the total short-term effective rate of 75.0%.After treatment,11 patients with pain were relieved in 9,and 8 with jaundice were subsided jaundice in 6.The adverse reactions included nausea and vomiting in 10 patients,leukocyte decrease in 7,and decreased platelet in 5,which became normal after symptomatic treatment.Conclusion SBRT combined with HIFU achieves a satisfactory result for advanced pancreatic cancer,and the adverse reactions are tolerable.

关 键 词：胰腺癌 中晚期 体部γ刀立体定向放疗 高强聚焦超声 

分 类 号：R735.9[医药卫生—肿瘤]