富马酸喹硫平对首发精神分裂症患者睡眠脑电活动的影响  

Influence of quetiapine fumarate on brain electrical activity during sleep in patients with first-episode schizophrenia

作　　者：闫润涛 马晓燕[2] 祖国平 石玉中[1] 娄百玉[1] 穆俊林[3] 

机构地区：[1]新乡医学院第二附属医院精神病科,河南新乡453002 [2]新乡医学院第二附属医院心身一科,河南新乡453002 [3]新乡医学院第二附属医院睡眠科,河南新乡453002

出　　处：《中华实用诊断与治疗杂志》2015年第1期98-99,共2页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的探讨首发精神分裂症患者服用富马酸喹硫平后睡眠脑电活动的变化。方法首次发病精神分裂症患者43例(观察组)分别于治疗前、服用富马酸喹硫平治疗4周后应用多导睡眠图进行整夜描记,记录总睡眠时间、睡眠潜伏期、睡眠效率、觉醒时间、快眼动睡眠潜伏期、快眼动睡眠时间及慢波睡眠1期占总睡眠时间百分比(S1%)、慢波睡眠2期占总睡眠时间百分比(S2%)、慢波睡眠3期+4期时间占总睡眠时间百分比(SWS%),并与36例体检健康者(对照组)进行比较。结果对照组总睡眠时间、睡眠潜伏期、睡眠效率、觉醒时间、快眼动睡眠潜伏期、快眼动睡眠时间及S1%、S2%、SWS%分别为(462.7±21.3)min、(18.6±9.8)min、(96.3±5.2)%、(14.8±5.5)min、(90.3±14.7)min、(99.1±13.4)min、(9.2±1.7)%、(55.7±4.2)%、(16.7±4.5)%;观察组治疗前分别为(372.4±29.8)min、(31.6±15.2)min、(86.6±9.4)%、(37.5±16.2)min、(64.7±22.6)min、(67.5±19.8)min、(22.8±9.6)%、(51.3±16.9)、(10.2±4.8)%),治疗4周后分别为(446.7±25.3)min、(24.9±11.2)min、(94.5±7.8)%、(21.4±9.7)min、(70.3±18.5)min、(83.1±16.3)min、(11.6±5.7)%、(58.7±5.1)%、(15.8±4.6)%,观察组治疗前除S2%外各指标与对照组比较差异有统计学意义(P<0.05),观察组治疗后总睡眠时间、睡眠效率、觉醒时间、S1%、S2%、SWS%与治疗前比较差异有统计学意义(P<0.05)。结论首发精神分裂症患者服用富马酸喹硫平后总睡眠时间增加、睡眠效率提高、觉醒时间减少、慢波睡眠1期睡眠减少、慢波睡眠2期和3期及4期睡眠增加。Objective To investigate the changes of brain electrical activity during sleep after the administration of quetiapine fumarate in patients with first-episode schizophrenia. Methods Forty-three patients with first-episode schizophrenia（observation group）underwent polysomnography before and after 4-week treatment with quetiapine fumarate to record the total sleep time,sleep latency,sleep efficiency,awakening time,rapid eye movement sleep latency,rapid eye movement sleep time,percentage of slow-wave sleep stage 1 in total sleep time（S1%）,percentage of slow-wave sleep stage 2 in total sleep time（S2%）,and percentage of slow-wave sleep stage 3 and 4 in total sleep time（SWS%）,and were compared with 36 healthy volunteers（control group）.Results The total sleep time,sleep latency,sleep efficiency,awakening time,rapid eye movement sleep latency,rapid eye movement sleep time,S1%,S2% and SWS% were（372.4±29.8）min,（31.6±15.2）min,（86.6±9.4）%,（37.5±16.2）min,（64.7±22.6）min,（67.5±19.8）min,（22.8±9.6）%,（51.3±16.9）% and（10.2±4.8）% before treatment,and（446.7±25.3）min,（24.9±11.2）min,（94.5±7.8）%,（21.4±9.7）min,（70.3±18.5）min,（83.1±16.3）min,（11.6±5.7）%,（58.7±5.1）% and（15.8±4.6）% after 4-week treatment in observation group,and were（462.7±21.3）min,（18.6±9.8）min,（96.3±5.2）%,（14.8±5.5）min,（90.3±14.7）min,（99.1±13.4）min,（9.2±1.7）%,（55.7±4.2）%,（16.7±4.5）% in control group.Significant differences were found in all indexes above except S2% between two groups（P〈0.05）.The total sleep time,sleep efficiency,awakening time,S1%,S2% and SWS% showed significant differences after treatment in comparison with before treatment in observation group（P〈0.05）.Conclusion Quetiapine fumarate can prolong the total sleep time,improve sleep efficiency,reduce awakening time,shorten slow-wave sleep stage 1,and prolong slow-wave sleep stage 2,3 and 4 for first-episode schizophrenia patients.

关 键 词：首发精神分裂症 多导睡眠图 富马酸喹硫平 

分 类 号：R749.3[医药卫生—神经病学与精神病学]