地佐辛与氟比洛芬酯或曲马多联合用于肺癌胸腔镜手术术后镇痛的临床观察  

Effects of Dezocine Combined with Flurbiprofen Axetil or Tramadol in the Postoperative Analgesia of Patients Treated with Thorascopic Surgery

作　　者：蒋大明[1] 鲁振[1] 王丽君[1] 

机构地区：[1]江苏省肿瘤医院麻醉科,江苏南京210009

出　　处：《肿瘤基础与临床》2014年第6期509-511,共3页journal of basic and clinical oncology

基　　金：江苏省肿瘤医院资助课题面上项目(编号:ZM201113)

摘　　要：目的：比较地佐辛与氟比洛芬酯或曲马多联合用于肺癌胸腔镜手术术后镇痛的效果及安全性。方法择期行胸腔镜下肺癌根治术患者60例随机均分为2组，每组30例，手术结束前30 min给予负荷量地佐辛0.1-0.15 mg·kg-1、托烷司琼6 mg。术后接患者自控静脉镇痛泵（2 mL·h-1）。地佐辛复合氟比洛芬酯组（ A组）镇痛泵配方为地佐辛0.5 mg·kg-1加氟比洛芬酯3 mg·kg-1，地佐辛复合曲马多组（ B组）为地佐辛0.5 mg·kg-1加曲马多10 mg·kg-1，2组均加托烷司琼6 mg。记录患者术后2、4、12、24、48 h的VAS疼痛评分、术后48 h内的按压次数和毒副反应。结果2组患者均获得良好的镇痛效果，术后各时间点的VAS评分及术后48 h患者自控静脉镇痛泵按压次数比较差异均无统计学意义（ P均〉0.05）；B组恶心呕吐发生率显著高于A组（P〈0.05）。结论在肺癌胸腔镜手术术后镇痛中，地佐辛复合氟比洛芬酯毒副反应轻且镇痛良好。Objective To compare the effects of dezocine combined with flurbiprofen axetil or tramadol in the postoperative analgesia of patients treated with thorascopic surgery. Methods Sixty patients scheduled for video-as-sisted thoracoscopic surgery were randomly divided into 2 groups. All the patients received an intravenous load dose of dezocine 0. 1-0. 15 mg·kg-1 and tropisetron 6 mg in the 30 min after surgery. Patient controlled analgesia pump （2 mL·h-1 ）was performed in all the patients. The formula of patient controlled analgesia in the group A was dezocine 0. 5 mg·kg-1 combined with flurbiprofen axetil 3 mg·kg-1 and tropisetron 6 mg;that of the B group was dezocine 0. 5 mg·kg-1 combined with tramadol 10 mg·kg-1 . VAS scores were recorded in the 2,4,12,24 and 48 h after the surgery. Automatic frequency and toxicities of patient controlled analgesia were also recorded in the 48 h after the surgery. Results All the patients of the two groups got favourable analgesia. No significant difference was observed between the two groups in the VAS scores at all the observed points and the automatic frequency in the 48 h after the surgery. The nausea and vomiting rate significant higher in the group B was than that in the group A. Conclusion Dezocine combined with flurbiprofen axetil is safe and effect in the postoperative analgesia of patients treated with thorascopic surgery.

关 键 词：氟比洛芬酯 曲马多 地佐辛 患者自控镇痛 胸腔镜 

分 类 号：R734.2[医药卫生—肿瘤] R730.56[医药卫生—临床医学]