NINJ2基因功能单核苷酸多态性与脑梗死的相关性研究  

The Association of NINJ2 gene Functional single-nucleotide polymorphisms with Cerebral Infarction

作　　者：冼文川[1] 李新梅[2] 朱薇薇[2] 

机构地区：[1]广东医学院附属医院神经内科,广东湛江524001 [2]湛江中心人民医院神经内科,广东湛江524001

出　　处：《中国实验诊断学》2014年第12期1996-1998,共3页Chinese Journal of Laboratory Diagnosis

基　　金：2012年湛江市科技攻关计划项目编号:2012C3102024

摘　　要：目的分析粤西地区汉族人群NINJ2基因功能单核苷酸多态性(Functional SNP,F-SNP)与脑梗死的关联性。方法采用FASTSNP软件筛选神经损伤诱导蛋白基因2(NINJ2)的F-SNPs(rs34578646A/G和rs3809263A/G)。联合聚合酶链反应-限制性片段长度多态性(PCR-RFLP)和等位基因特异性PCR(AS-PCR)方法,对278例脑梗死患者(病例组)和120例正常对照者(对照组)进行F-SNPs基因型检测。结果病例组rs34578646 A/G和rs3809263A/G的基因型频率和等位基因频率与对照组相比较差异无统计学意义(P>0.05)。结论粤西地区汉族人群NINJ2基因功能单核苷酸多态性rs34578646A/G以及rs3809263A/G与脑梗死无关。Objective To investigate the relationship between cerebral infarction （CI）and the functional single nu-cleotide polymorphisms（F-SNPs ）of NINJ2 gene in Han population of the Western Guangdong province in China. Methods The F-SNPs of NINJ2 gene （rs34578646 A/G and rs3809263 A/G）was screened by FASTSNP software. Genotype and allele frequency was analysis in 278 cerebral infarction cases and 120 healthy controls.Results The fre-quencies of genotypes and allele in two polymorphisms （rs34578646 A/G and rs3809263 A/G）showed an insignificant difference between case and control groups（P〉0.05）.Conclusion Two F-SNPs of NINJ2 gene （rs34578646 A/G and rs3809263 A/G）were not associated with the risk of ischemic stroke.

关 键 词：NINJ2基因 脑梗死 功能单核苷酸多态性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]