脉络膜血管瘤的超声造影特征  

Contrast-enhanced ultrasound characteristics of choroidal hemangioma

作　　者：佘海澄[1] 李栋军[1] 杨文利[1] 陈伟[1] 王子杨[1] 魏文斌[1] 

机构地区：[1]首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科学与视觉科学重点实验室,北京100730

出　　处：《中华实验眼科杂志》2015年第1期51-54,共4页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金项目（81272981）;北京市自然科学基金项目（7112031）;北京市卫生系统高层次卫生技术人才培养计划项目（2009-3-32）

摘　　要：背景 脉络膜血管瘤是常见的跟部良性肿瘤,典型病例通过临床检查易于诊断,但不典型病例易误诊为眼部恶性肿瘤.超声造影,即对比增强超声（CEUS）是近年来用于占位性病变临床诊断的影像学检查技术,但在眼科的应用较少. 目的 研究脉络膜血管瘤CEUS的表现特点. 方法 对2010年7月至2012年12月在北京同仁医院经临床综合检查诊断为脉络膜血管瘤的58例58眼进行CEUS检查,并分析其CEUS特点.应用时间-强度分析分别对脉络膜血管瘤及正常眼眶组织的显影上升时间（RT）、达峰时间（TTP）、峰值强度（MI）及平均渡越时间（mTT）进行测量和定量比较,并采用配对秩和检验对检查结果的差异进行比较.结果 CEUS检查显示,脉络膜血管瘤患者注射造影剂后随时间的推移,病灶完全显影,并呈高信号影像,显影的消退时间迟于正常眶内组织.脉络膜血管瘤病灶MI、RT、TTP和mTT分别为294.20％（217.35％,373.25％）、21.30（17.35,23.35）s、25.00（21.68,27.48）s和59.30（51.08,78.35）s,其中位数明显大于正常眶内组织的100.00％（100.00％,100.00％）、17.75（15.00,20.30）s、22.40（18.35,24.63）s和47.25（40.90,57.23）s,差异均有统计学意义（Z=-6.608,-4.998,-4.650,-4.332,均P＜0.001）.结论 脉络膜血管瘤的CEUS表现具有特异性,有助于脉络膜血管瘤的鉴别诊断.Background Choroidal hemangioma is a common benign intraocular tumor.Typical choroidal hemangioma is comparably easy to diagnose,but untypical one might be misdiagnosed as malignant tumor.Contrastenhanced ultrasound （CEUS） has been used to diagnose multiple neoplasm for the past few years.However,the application of CEUSin ophthalmology is less.Objective This study was to investigate the CEUS characteristics of choroidal hemangioma.Methods Fifty-eight eyes of 58 patients who were diagnosed as choroidal hemangioma were included in Beijing Tongren Hospital during July 2010 to December 2012.CEUS was performed on the patients to check the manifestations of choroidal hemangioma.A time-intensity analysis was employed to quantitatively analyzed and compared the maximum intensity （MI）,rising time （RT）,time to peak （TTP）,and mean transit time （mTT） between the choroidal hemangioma and normal orbital tissue and the parameters were contrasted using Wilcoxon signed-rank test.Results CEUS showed that choroidal hemangioma was gradually enhanced by the contrast after intravenous injection of sulphur hexafluoride microbubbles with a high-reference signal in choroidal hemangioma,and the fading procedure was slower in choroidal hemangioma than that of normal orbital tissue.MI,RT,TTP,and mTT were294.20% （217.35%,373.25%）,21.30 （17.35,23.35） s,25.00 （21.68,27.48） s and 59.30 （51.08,78.35） s in the choroidal hemangioma,which were significantly higher than 100.00% （100.00%,100.00%）,17.75 （15.00,20.30） s,22.40 （18.35,24.63） s and 47.25 （40.90,57.23） s in the normal orbital tissue （Z =-6.608,-4.998,-4.650,-4.332,all at P〈0.001）.Conclusions Choroidal hemangioma has its own CEUS manifestation characteristics.CEUS is helpful to the differential diagnosis of choroidal hemangioma.

关 键 词：脉络膜 脉络膜肿瘤/诊断 血管瘤/诊断 对比增强超声 

分 类 号：R739.7[医药卫生—肿瘤]