乳腺单纯型小管癌45例的临床病理特征及预后分析  

Clinicopathological characteristics and prognostic analysis of pure tubular carcinoma of breast:45 cases

作　　者：马园园[1] 陆苏[1] 冯新熠 刘红[1] 

机构地区：[1]天津医科大学肿瘤医院乳腺二科,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室,乳腺癌防治教育部重点实验室,天津300060

出　　处：《肿瘤》2015年第1期78-83,共6页Tumor

摘　　要：目的:分析并探讨乳腺单纯型小管癌(pure tubular carcinoma,PTC)的临床病理特征、预后和治疗。方法:收集2004年1月—2008年12月天津医科大学肿瘤医院经病理确诊的PTC患者45例,回顾性分析其临床病理资料及预后情况。结果:乳腺PTC患者的腋窝淋巴结转移率较低(13.98%),并且腋窝淋巴结转移个数较少(均未超过3个)。p53(P=0.044)表达水平以及是否是双侧乳腺癌(P=0.004)与PTC预后相关,但并非PTC预后的独立影响因素。本组45例乳腺PTC患者的5年无病生存率为91.1%,5年总生存率为100.0%。放疗与乳腺PTC患者的预后(P=0.300)并无显著相关性。结论:乳腺PTC患者腋窝淋巴结转移率低,预后好;前哨淋巴结活检或许可以替代腋窝淋巴结清扫,以减少术后并发症的发生,提高患者生活质量。对3个及以上淋巴结转移的乳腺PTC患者,是否进行放疗还需进一步研究和讨论。Objective：This study aims to analyze and identify the clinicopathology,prognosis and therapy of patients with breast pure tubular carcinoma（PTC）.Methods：A retrospective analysis of clinicopathology and outcomes in45 patients with breast PTC from January 2004 to December 2008 at Tianjin Medical University Cancer Hospital was performed.Results：The incidence rate of lymph node metastasis was low while the less number of positive lymph nodes in patients with axillary lymph node metastasis（not more than three）.It was also found that p53（P = 0.044） and bilateral breast cancer（P = 0.004） were risk factors affecting the disease-free survival of breast PTC according to univariate analysis,while the regression model analysis showed that they were not independent risk factors affecting prognosis of PTC.The 5-year diease-free survival was 91.1%,meanwhile the 5-year overall survival was 100.0%in 45 patients with breast PTC.Radiotherapy（P=0.300） didn＇t show a significant effect on the prognosis of patients with breast PTC.Conclusion：The axillary lymph node cleaning may be replaced with sentinel lymph node biopsy based on the low rate of lymph node metastasis and good prognosis,in order to reduce the occurrence of postoperative complications and improve the quality of life.For breast PTC patients with more than three axillary lymph node metastasis,the use of radiotherapy still need further studies and should be discussed.

关 键 词：乳腺肿瘤 单纯型小管癌 预后 治疗 

分 类 号：R737.9[医药卫生—肿瘤]