胃癌组织中zeb-1和c-jun蛋白的表达及意义  

Expression of zeb-1 and c-jun in gastric carcinoma and its significance

作　　者：王智勇[1] 吴继锋[1,2] 

机构地区：[1]安徽医科大学基础医学院病理学教研室,合肥230032 [2]安徽医科大学第一附属医院病理科,合肥230022

出　　处：《临床与实验病理学杂志》2015年第1期48-51,共4页Chinese Journal of Clinical and Experimental Pathology

基　　金：安徽省高校省级自然科学研究重点项目(KJ2012A159);国家临床重点专科建设项目经费资助

摘　　要：目的探讨胃癌组织中zeb-1和c-jun蛋白的表达及对肿瘤发生、发展的影响。方法采用免疫组化PV两步法检测100例胃癌及癌旁组织中zeb-1、c-jun和E-cadherin的表达。结果胃癌组织中zeb-1、c-jun和E-cadherin的阳性率分别为81%、70%、35%;癌旁组织中zeb-1、c-jun和E-cadherin的阳性率分别为17%、25%、100%。zeb-1和c-jun蛋白在胃癌组织中的表达均显著高于癌旁组织(P<0.05)。zeb-1表达与肿瘤浸润深度、分化程度、淋巴结转移、TNM分期有关(P<0.05);与患者年龄、性别、肿块大小无相关性。c-jun表达与肿瘤分化程度有关(P<0.05),与其它临床病理特征无相关性。zeb-1与E-cadherin在胃癌组织中表达呈负相关(P<0.05),zeb-1与c-jun在胃癌组织中表达呈正相关。zeb-1与c-jun高表达者术后5年生存率明显低于低表达者。结论 zeb-1与c-jun高表达与胃癌的发生、发展密切相关,可作为判断胃癌预后的指标。Purpose To study the expression of zeb-1 and c-jun in gastric cancer and its influence of occurrence and development of tumor. Methods The expression zeb-1,c-jun and E-cadherin were assessed in 100 specimens of gastric cancer and their tissue adjacent to cancer by immunohistochemistry. Results The positive rates of zeb-1,c-jun and E-cadherin expression in gastric cancer were81%,70%,35%,and in tissue adjacent to cancer were 17%,25%,100%. The expression of zeb-1 and c-jun in gastric cancer were higher than those in their tissue adjacent to cancer（ P 〈 0. 05）. zeb-1 expression was closely correlated with the degree of tumor differentiation,depth of invasion,lymph node metastasis and TNM stage（ P 〈 0. 05）,which were not correlated with patient s age,sex and tumor size. c-jun expression was closely correlated with the degree of tumor differentiation（ P 〈 0. 05）,which were not correlated with other pathological features. The expression of zeb-1 was negatively correlated with the expression of E-cadherin and was positively correlated with the expression of c-jun in gastric cancer. Patients with high expression of zeb-1 and c-jun had lower five-year survival rate than patients with negative expression. Conclusion zeb-1 and c-jun are closely correlated with occurrence and development of gastric cancer. They can be a index of judging prognosis of gastric cancer.

关 键 词：胃肿瘤 上皮细胞-间质转化 zeb-1 C-JUN 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤] R36-33[医药卫生—临床医学]