ER和PR同一表达状态下HER-2与乳腺癌X线表现的相关性分析  

Correlation Analysis of HER-2 and Mammographic Features of Breast Cancers with ER and PR in the Same Expression Condition

作　　者：刘小庆[1] 林青[1] 崔春晓[1] 蒋珍妮[1] 边甜甜[1] 

机构地区：[1]青岛大学附属医院乳腺影像科,266100

出　　处：《临床放射学杂志》2015年第1期31-35,共5页Journal of Clinical Radiology

基　　金：青岛市公共领域科技支撑计划项目(编号:2012-1-3-2-(8)-NSH)

摘　　要：目的探讨乳腺癌免疫组织化学中雌激素受体(ER)和孕激素受体(PR)表达一致条件下,人类表皮生长因子受体2(HER-2)的表达状态和乳腺癌X线表现之间的相关性。方法回顾性分析经手术病理确诊的1533例女性乳腺癌患者的X线表现,根据免疫组织化学(IHC)中HER-2、ER、PR的表达结果分为Ⅰa(HER-2阳性/ER-/PR-)和Ⅰb(HER-2阴性/ER-/PR-)、Ⅱa(HER-2阳性/ER+/PR+)和Ⅱb(HER-2阴性/ER+/PR+)两个配对组。分别对两个配对组中乳腺癌的肿块和钙化进行分析,并对各项分析结果进行统计学检验。结果Ⅰa和Ⅰb组中,HER-2表达阳性乳腺癌多见单纯钙化(18.3%)、肿块伴钙化(23.7%),HER-2表达阴性乳腺癌单纯肿块比较多见(49.2%);HER-2表达阳性乳腺癌肿块形态以不规则形多见(47.4%),HER-2表达阴性乳腺癌肿块以类圆形(58.8%)、分叶状(12.1%)多见;HER-2表达阳性乳腺癌肿块边界多模糊不清(86.1%),HER-2表达阴性乳腺癌肿块边界多清楚局限(9.8%)。与HER-2表达阳性乳腺癌比较,阴性乳腺癌砂砾状钙化(55.2%)多见,且大多呈区域性分布(32.1%)。Ⅱa和Ⅱb组中,HER-2表达阳性乳腺癌类圆形(52.1%)、分叶状肿块(11.0%)多见,HER-2表达阴性乳腺癌不规则形肿块(40.6%)多见;HER-2表达阳性乳腺癌肿块边界多模糊不清(90.7%),大多可见毛刺边缘(66.7%),HER-2表达阴性乳腺癌肿块边缘多见浅分叶(65.3%)。与HER-2表达阴性乳腺癌比较,阳性乳腺癌砂砾状钙化(68.4%)多见,且大多呈节段性分布(31.9%),HER-2表达阴性乳腺癌钙化大多成簇状分布(57.6%)。结论各配对组中HER-2表达阳性与阴性乳腺癌的肿块及钙化有着不同的X线表现。Objective To investigate the relationship between HER-2 status and mammographic imaging features under the condition that ER and PR are in the same expression levels. Methods A total of 1533 females with pathologically- proved breast cancer were enrolled in this study. Preoperative mammographic findings were retrospectively analyzed. Ac- cording to the expression of HER-2. ER and PR determined by immunohistochemical study, the patients were divided into two matched-pair groups： Ia （positive HER-2, negative ER and PR） and Ib （negative HER-2, and negative ER and PR） ; IIa （ positive HER-2, positive ER and PR） and IIb（ negative HER-2, positive ER and PR）. The mass form and the calci- fication of the breast cancer were determined, and the results were statistically analyzed and compared between the two matched-pair groups. Results In Ia and Ib matched-pair group, the breast cancers with positive HER-2 showed simple calcifications （18.3%）, mass with calcifications （23.7%） ; while the breast cancers with negative HER-2 mainly presen- ted as simple mass （49.2%）. The lesions of positive HER-2 breast cancer were mainly irregular in shape （47.4%）, while the lesions of negative HER-2 breast cancer were mainly oval （58.8%） or lobulated （ 12.1% ） in shape. The lesions of positive HER-2 breast cancer usually had a blur margin （86.1% ）, while the lesions of negative HER-2 breast cancer u- sually had a clear border （9.8%）. Compared with positive HER-2 breast cancer, the negative HER-2 breast cancer usual- ly had grit calcification （55.2%） which was regionally distributed （32.1%）. In IIa and IIb matched-pair group, the breast cancers with positive HER-2 were mainly oval （52.1% ） or lobulated （11.0% ） in shape, while the lesions of nega- tive HER-2 breast cancer were mainly irregular in shape （40.6%）. The lesions of positive HER-2 breast cancer usually had a blur margin （90. 7% ） 2 with spicnlation （66.7%）, while the lesions of negative HER-2 breast canc

关 键 词：乳腺肿瘤 乳房X线摄影术 受体 erbB-2 受体 雌激素 受体 孕酮 

分 类 号：R737.9[医药卫生—肿瘤]