强迫症患者情绪Stroop任务的事件相关电位研究  被引量:8

Event-related potentials of non-mediated obsessive-compulsive disorder patients in an emotional Stroop task

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作  者:樊洁[1] 钟明天[2] 朱熊兆[1] 雷辉[1] 董姣姣[1] 周晟[1] 刘婉婷[1] 

机构地区:[1]中南大学湘雅二医院医学心理学研究所,长沙410011 [2]湖南师范大学心理应用研究中心

出  处:《中华行为医学与脑科学杂志》2015年第1期20-23,共4页Chinese Journal of Behavioral Medicine and Brain Science

基  金:国家自然科学基金资助项目(81371487)

摘  要:目的探讨强迫症患者和正常对照组被试注意控制的异同和其神经机制。方法记录26名强迫症患者和24名正常对照组在执行情绪Stroop任务时诱发的事件相关电位(ERPs)。结果强迫症患者整体反应时[(467±14.88)ms]长于正常对照组[(409.65±15.49)ms],差异具有统计学意义(P〈0.01);强迫症患者整体的P2和P3波幅[分别为(10.41±0.49)μV,(10.04±0.68)μV]大于正常对照组[分别为(8.89±0.48)μV,(7.68±0.67)μV],均差异具有统计学意义(P〈0.05);强迫症患者额区P2成分的潜伏期[(190.09+4.71)ms]长于正常对照组[(179.60±4.72)ms],差异具有统计学意义(P〈0.05)。结论强迫症患者对一般负性刺激不存在注意偏向,但有普遍的注意抑制困难。Objective To study the difference of attentional bias towards general negative words between non-mediated obsessive-compulsive disorder (OCD) patients and healthy controls.Methods Event-related potentials (ERPs) were collected from 26 non-mediated OCD patients and 24 normal controls while they performed an emotional Stroop task. Results Compared to healthy controls, OCD patients showed significantly longer reaction time ( OCD : ( 467 ±14.88 ) ms, Controls : ( 409.65± 15.49) ms, P〈0.01 ) , and had significantly larger P2 and P3 amplitude to all three types of words (P2 amplitude:OCD : (10.41±0.49)p.V, Controls:(8.89±0.48) μV P〈0.05 ;P3 amplitude:(10.04±0.68)μV, Controls:(7.68±0.67) μV, t〉〈0.05). In addition,the P2 peak latency of the frontal area in OCD patients was significantly longer than that in healthy controls (OCD:( 190.09±4.71 ) ms, Controls: (179.60±4.72) ms, P〈0.05).Conclusion Current findings suggest that OCD patients are characterized by a gen- eral attentional inhibition deficit but not an attentional bias to the negative words.

关 键 词:强迫症 情绪stroop任务 事件相关电位 注意偏向 

分 类 号:R749.7[医药卫生—神经病学与精神病学]

 

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