儿茶酚氧位甲基转移酶基因多态性与精神分裂症患者记忆功能及阿立哌唑疗效的关联研究  

Association study between catechol-O-methyltransferase Val158Met polymorphism and the memory function of schizophrenia treated with Aripiprazole

作　　者：范强 高树贵 李广学[3] 成佳 徐永明 谢曙光 

机构地区：[1]宁波市安康医院,宁波315000 [2]宁波市康宁医院 [3]宁波大学医学院

出　　处：《中华行为医学与脑科学杂志》2015年第1期31-34,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：宁波市自然科学基金项目（2013A610249）、（2009A610186）

摘　　要：目的探讨儿茶酚氧位甲基转移酶（catechol-0-methyltransferase，COMT）基因Vall58Met多态性与精神分裂症（schizophrenia，SCZ）患者记忆功能及阿立哌唑治疗效果的相关性。方法以DSM—IV为诊断标准，纳入中国汉族精神分裂症患者78例，应用聚合酶链反应-限制性片段长度多态性（PCR—RFLP）技术进行基因分型。采用中国韦氏记忆修订量表（WMS—RC），分别于阿立哌唑单一药物}台疗前及治疗8周后进行测评。并采用t检验、秩和检验、单因素方差分析方法进行统计学分析。结果三组基因型患者累积记忆差异具有统计学意义（F=12．371，P=0．002），Met／Met基因型患者较Vai／Met、Val/Val基因型患者累积记忆差（z=-3．168，-2．641；P=0．002，0．008）；经阿立哌唑治疗8周后，除联想记忆外，患者记忆功能均有明显改善（P〈0．05）。并且不同基因型患者累积记忆改善差异具有统计学意义（F=8．570，P〈0．01），Me∥Met基因型患者较Val／Met、Val／Yal基因型患者累积记忆改善更好（t=4．203，3．024，均P〈0．01）。结论COMT基因Vall58Met多态性可能与精神分裂症患者累积记忆及相应阿立哌唑疗效存在相关性。Met/Met基因型患者表现出更差的累积记忆能力和更好的药物反应性。Objective To investigate the association between catechol-O-methyltransferase （COMT） Val158Met polymorphism and the memery function of schizophrenia treated with Aripiprazole. Methods Schizophrenic patients were diagnosed in according to Diagnostic and Statistical Manual of Mental Disorders-IV （DSM-IV） .A total of 78 Chinese Han subjects were involved in this study.The polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） was used to identify COMT genotypes. The Chinese revised version of Wechsler Memory Scale （WMS-RC） was used twice to evaluate the memory function of patients treated with Aripiprazole alone before and after drug treatment for 8 weeks. ANOVA, rank sum test and t -test were used to statistical analysis. Results There was statistical difference of cumulative memory among the three groups （F = 12.371, P=0.002）, and Met/Met genotype showed much poorer cumulative memory than Val/Met and Val/Val genotypes（Z=-3.168,-2.641 ; P= 0.002,0.008 ,respectively）Memory function was significantly improved after patients been treated with Aripiprazole except the associative memory（P〈0.05）. Met/Met genotype showed more improvement of cumulative memory than other genotypes after Aripiprazole treatment （ t= 4.203, P〈0.01 ; t= 3.024, P 〈0.01 ,respectively）. Conclusions There may be a relationship between COMT Val158Met polymorphism and the memory function of schizophrenia in Aripiprazole treatment. Met/Met genotype of schizophrenia showed worst cumulative memory but best responsiveness in Aripiprazole treatment.

关 键 词：精神分裂症 儿茶酚氧位甲基转移酶 阿立哌唑 记忆功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]