中国人群5-HT2A受体基因T102C与精神分裂症患者关联性的Meta分析  

Meta analysis on the relationship between 5-hydroxytryptamine 2A receptor gene polymorphism T102C and schizophrenia

作　　者：黄月薪[1] 吴娴波[1] 吴晓翔[2] 

机构地区：[1]南方医科大学公共卫生与热带医学学院流行病学系,广州市510515 [2]广州军区广州总医院附属第157医院神经外科

出　　处：《中华行为医学与脑科学杂志》2015年第1期92-95,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目（81373098）;广东省医学科研基金（WSTJJ20130419330825197010100064）;广东省科技计划项目（20128031800132）

摘　　要：目的探讨5-羟色胺2A（5-hydroxytryptamine，5-HT2A）受体基因T102C多态性与精神分裂症患者相关性。方法检索EMBASE、PubMed、CBM、CNKI、万方等数据库，收集在中国地区进行的与5-HT2A受体基因T102C多态性研究相关的文献，按照纳入与排除标准筛选整理相关数据后用Revman5．0软件进行Meta分析，并进行文献发表偏倚检验。结果检索到相关研究56篇，纳入符合标准的11篇文献，共收集4728个研究个体，其中研究组例数2135例，对照组人数2593人。各研究均符合Hardy—Weinberg平衡（均P〉0．05），Meta分析结果显示5-HT2A受体基因T102C多态性等位基因模型（TvsC）、隐性基因模型（CC＋CT）vs TT和共显性基因模型（TT vsCC和CT口sCC）三种基因模型差异无显著统计学意义（均P〉0．05）。显性基因模型（CT＋TF）vsCC分析结果I2=45％有中度异质性，但采用亚组分析法去除Ni等的数据分析时I2=9％，Z=2．01，P〈0．05。结论5-HT2A受体基因T102C位点C等位基因为隐性基因，CC可能是治病因子，需待进一步循征研究提供证据。Objective To assess the association of 5-hydroxytryptamine 2A （5-HTEA） receptor gene poly- morphism with schizophrenia by Meta analysis. Methods Literatures on the relationship between 5-HT2a receptor gene polymorphism T102C and the Chinese schizophrenia in EMBASE, PubMed, CBM, CNKI and Wanfang Med Online were taken as research objects.Screening the relevant data according to the included and excluded standard , then, Software of RevMan 5.0 was employed to do Meta analysis. Meanwhile, we inspect the literatures publication bias.Results Twelve literatures were included,collecting 4 728 individuals , enrolling 2 135 for the schizophrenia group and 2 593 for the control group.The research conforms to Hardy Weinberg equilibrium （ all P〉0.05 ） .The Meta analysis results showed that there was no significant association between 5-HT2A receptor gene polymorphism and schizophrenia including the allele model,recessive model and codominant model genotypes（ all P〉0.05）. The results of Dominant genetic model 12= 45% with moderate heterogeneity,but we used subgroup analysis to remove the author Ni＇s data ,there were significant difference analysis （ 12= 9%, Z= 2.01, P〈0.05）.Conclusions 5-HT2A receptor gene T102C site C allele is recessive genes,CC may be a healing factor,there needs evidence-based study provides further evidence.

关 键 词：精神分裂症 5-HT2A受体基因 T102C多态性 META分析 

分 类 号：R749.3[医药卫生—神经病学与精神病学]