Cortactin及FAKPY397在非小细胞肺癌中的表达及关系  

Expression and correlation of cortactin and focal adhesion kinase PY397 in non- small cell lung cancer

作　　者：孙波[1] 于涓瀚[1] 齐新阳 邱雪杉[1] 

机构地区：[1]中国医科大学基础医学院病理教研室,辽宁沈阳110001 [2]中国医科大学附属第一医院病理科,辽宁沈阳110001

出　　处：《现代肿瘤医学》2015年第4期464-467,共4页Journal of Modern Oncology

摘　　要：目的:探讨皮层肌动蛋白(cortactin)及磷酸化黏着斑激酶(focal adhesion kinase PY397,FAKPY397)在非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达情况及与临床病理因素之间的关系。方法:采用免疫组织化学方法检测114例NSCLC及相应癌旁正常肺组织中cortactin及FAKPY397的表达情况。结果:Cortactin在正常肺组织中表达阳性率为19.3%(22/114),显著低于其在NSCLC组织中的阳性率为57.9%(66/114,P<0.001)。Ⅲ、Ⅳ期组中cortactin表达阳性率为78.8%(26/33)显著高于Ⅰ、Ⅱ期组的49.4%(40/81,P=0.004),有淋巴结转移组中cortactin阳性率为74.0%(37/50)显著高于无淋巴结转移组的45.3%(29/64,P=0.002)。FAKPY397在正常肺组织中表达阳性率为25.4%(29/114),显著低于其在NSCLC组织中的阳性率为52.6%(60/114)。Ⅲ、Ⅳ期组中FAKPY397的表达阳性率为69.7%(23/33)显著高于Ⅰ、Ⅱ期组中的阳性率为45.7%(37/81,P=0.020),有淋巴结转移组中FAKPY397阳性率为64.0%(32/50)显著高于无淋巴结转移组的43.8%(28/64,P=0.032)。Speaman相关性分析表明在NSCLC中,cortactin的表达与FAKPY397的表达呈正相关(r=0.436,P<0.01)。结论:NSCLC中cortactin的表达与FAKPY397的表达呈正相关,二者协同表达可能是促进NSCLC进展的因素之一。Objective：To investigate the expression of cortactin and focal adhesion kinase PY397 （FAKPY397） in non- small cell lung cancer（NSCLC） and their correlation with clinicopathological factors. Methods：The expression of cortactin and FAKPY397 in 114 NSCLC specimens and adjacent normal tissues were detected by immunohisto- chemical method. Results：The positive expression rate of cortactin in NSCLC was 57.9% （66/114）, much higher than that in normal lung tissues 19.3% （22/114 ） （P 〈 0. 001 ）. Cortactin expression was significantly associated withlymph node metastasis （ P = 0. 002 ） and advanced TNM stage （ P = 0. 004 ）. The positive expression rate of FAK PY397 in NSCLC was 52.6% （60/114） ,much higher than that in normal lung tissues 25.4% （29/114,P 〈0. 001 ）. The expression of FAKPY397 was significantly associated with lymph node metastasis （ P = 0. 032） and advanced TNM stage（P = 0.020）. Spearmang result showed that the expression of cortactin was correlated with expression of FAKPY397 （ r = 0. 436, P 〈 0.01 ）. Conclusion ： Increased cortactin and FAKPY397 expression in NSCLC was associ- ated with lymph node metastasis and advanced TNM stages. Cortactin expression, in association with FAKPY397 expression, may play a role in tumor progression of NSCLC.

关 键 词：皮层肌动蛋白 磷酸化黏着斑激酶 非小细胞肺癌 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]