Ang-2及VEGF在多发性骨髓瘤中的表达及意义  

Expression and significance of Ang- 2 and VEGF in multiple myeloma

作　　者：周梅玲[1] 陈雁[1] 刘瑜[1] 汪香[1] 宋斌[1] 

机构地区：[1]湖北医药学院附属太和医院血液内科,湖北十堰442000

出　　处：《现代肿瘤医学》2015年第4期542-544,共3页Journal of Modern Oncology

摘　　要：目的:探讨血管生成素-2(Ang-2)及内皮生长因子(VEGF)在多发性骨髓瘤(MM)中的表达与意义。方法:ELISA法检测20例初发MM患者,14例疾病缓解患者(3例完全缓解,11例部分缓解),18例疾病进展患者,16例疾病复发患者血清中Ang-2与VEGF的水平,并与正常对照组比较。结果:MM初发组、疾病进展组、复发组患者血清Ang-2及VEGF水平显著高于正常对照组(P<0.01);缓解组Ang-2及VEGF水平与初发组相比显著下降(P<0.01),与正常对照组相比差异无统计学意义(P>0.05);复发及疾病进展的患者Ang-2及VEGF水平显著高于缓解组(P<0.01);初发MM血清Ang-2水平与VEGF水平呈正相关性(r=0.48,P<0.05)。结论:Ang-2及VEGF参与了MM的发病且可能具有协同作用,Ang-2及VEGF有望成为治疗MM的新靶点。Objective： To discuss the expression and significance of Ang- 2 and VEGF in multiple myeloma. Methods ： Serum levels of Ang - 2 and VEGF in 20 initial, 14 remission （3 eases of complete remission, 11 cases of partial remission）, 18 disease progression and 16 relapsed patients with multiple myeloma were determined by enzyme -linked immunosorbent assay （ELISA） , and compared with normal controls. Results：The serum levels of Ang -2 and VEGF in initial, disease progression and relapsed patients with multiple myeloma was significantly higher than that of control group （P 〈 0.01 ）. Compared with the initial group , the serum levels of Ang -2 and VEGF in remis- sion patients decreased significantly（P 〈0.01 ） and had no significantly difference from those in control group （P 〉 0.05）. In disease progression and relapsed patients, the serum levels of Ang - 2 and VEGF were significantly higher than those in remission patients （P 〈 0.01 ）. There were positive correlation between the serum levels of Ang -2 and VEGF in initial multiple myeloma（ r = 0.48, P 〈 0.05 ）. Conclusion： Serum levels of Ang - 2 and VEGF are closely related with occurrence of multiple myeloma and may have synergistic effect, Ang - 2 and VEGF may be a new target in the treatment of muhiple myeloma.

关 键 词：多发性骨髓瘤 血管生成素-2 血管内皮生长因子 

分 类 号：R733.3[医药卫生—肿瘤]